Oligospermines for non-viral siRNA delivery

机译：寡精胺用于非病毒性siRNA递送

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In this thesis, delivery systems for siRNA delivery are introduced with special attention to non-viral vectors. Many successful vectors used in vivo were reviewed. Our work focused on the effect of different architectures of oligospermine polmers on their suitability for siRNA delivery in lung cancer cells. Different archituctures showed different polyplex structures and variable transfection efficiencies. Moreover, we presented a review on nanoimprint lithography techniques with an outlook on possible biological applications in the field of gene and drug delivery.

机译：在本文中，介绍了用于siRNA递送的递送系统，特别注意非病毒载体。审查了体内成功使用的许多载体。我们的工作集中在寡精胺聚合物不同结构对其在肺癌细胞中传递siRNA的适用性的影响。不同的体系结构显示了不同的多链体结构和可变的转染效率。此外，我们提出了关于纳米压印光刻技术的综述，展望了基因和药物递送领域中可能的生物学应用。

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作者
Elsayed, Maha.;
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作者单位

Wayne State University.;

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授予单位 Wayne State University.;
学科 Pharmaceutical sciences.;Nanoscience.;Nanotechnology.
学位 M.S.
年度 2013
页码 143 p.
总页数 143
原文格式 PDF
正文语种 eng
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专利

1. Enhanced Intercellular Delivery of cRGD–siRNA Conjugates by an Additional Oligospermine Modification [J] . Kosuke Nakamoto, Yukihiro Akao, Yasuhiro Furuichi, ACS Omega . 2018,第7期

机译：额外的寡精胺修饰增强了cRGD-siRNA的细胞间传递。
2. Influence of Oligospermines Architecture on Their Suitability for siRNA Delivery [J] . Maha Elsayed, Vincent Corrand, Vidula Kolhatkar Biomacromolecules . 2014,第4期

机译：oligospermines架构对siRNA交付适用性的影响
3. In vitro investigations of the efficacy of cyclodextrin-siRNA complexes modified with lipid-PEG-octaarginine: Towards a formulation strategy for non-viral neuronal siRNA delivery [J] . OMahonyA.M., DesgrangesS., OgierJ., Pharmaceutical research . 2013,第4期

机译：脂质-PEG-八精氨酸修饰的环糊精-siRNA复合物功效的体外研究：制定非病毒神经元siRNA传递的配方策略
4. Non-viral (polymeric) delivery of combinational siRNAs against cell cycle and phosphatase proteins to prevent metastasis in breast cancer [C] . Manoj Parmar, Remant Bahadur Kc, Robert Maranchuk, World biomaterials congress . 2016

机译：siRNA的非病毒（聚合）递送可抵抗细胞周期和磷酸酶蛋白，从而预防乳腺癌的转移
5. Development of a Non-viral Delivery System for siRNA in Treatment of Lymphoma. [D] . Sahin, Basak. 2013

机译：siRNA治疗淋巴瘤的非病毒递送系统的开发。
6. Enhanced Intercellular Delivery of cRGD–siRNAConjugates by an Additional Oligospermine Modification [O] . Kosuke Nakamoto, Yukihiro Akao, Yasuhiro Furuichi, 2018

机译：cRGD-siRNA的细胞间传递增强通过额外的寡精胺修饰进行缀合
7. Enhanced Intercellular Delivery of cRGD–siRNA Conjugates by an Additional Oligospermine Modification [O] . Kosuke Nakamoto, Yukihiro Akao, Yasuhiro Furuichi, 2018

机译：通过额外的低喹啉改性增强CRGD-siRNA缀合物的细胞间递送

Oligospermines for non-viral siRNA delivery

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