• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Linking the exposure/dose relationship for 2,2',4,4'-tetrabromodiphenyl ether (BDE 47) in mice: Potential implications for human health risk assessment.
【24h】

Linking the exposure/dose relationship for 2,2',4,4'-tetrabromodiphenyl ether (BDE 47) in mice: Potential implications for human health risk assessment.

机译：链接小鼠中2,2'，4,4'-四溴二苯醚（BDE 47）的暴露/剂量关系：对人类健康风险评估的潜在影响。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Despite its small contribution to global production and usage of polybrominated diphenyl ethers, BDE 47 is the major flame-retardant congener found in environmental samples and human tissue. Limited toxicology studies suggest that BDE 47 is a developmental reproductive and neurotoxicant, as well as an endocrine disrupter. This dissertation investigates the link between exposure, dose, and response needed for the risk assessment of BDE 47. We hypothesized that BDE 47 is a persistent, bioaccumulative and toxic chemical that has toxicokinetic properties similar to other polyhalogenated aromatic hydrocarbons. To test this hypothesis and provide information essential to the human health risk assessment of BDE 47: the basic toxicokinetic parameters of BDE 47 were characterized in mice, the impact of repeated dosing on the disposition and excretion of BDE 47 and the disposition and excretion of BDE 47 in a developmental model were investigated, the mechanism of rapid BDE 47 excretion in mice was researched, and the toxicokinetics of BDE congeners 47, 99, 100, and 153 toxicokinetics were compared.; In adult, female mice, BDE 47 is well absorbed, distribution is dictated by lipophilicity, metabolism is a minor component of elimination, and has a terminal whole-body half life of 22 days. Repeated exposure results in higher body burdens than a single exposure alone, therefore demonstrating the potential for bioaccumulation. BDE 47 has toxicokinetic properties similar to other polyhalogenated aromatic hydrocarbons with the exception of a rapid urinary excretion process. Tissue distribution in developing animals is similar to adults; however, actual concentrations are higher in younger animals because of a reduced ability to excrete BDE 47. Several efforts to characterize the mechanism of rapid renal excretion resulted in a narrowed field of active transport proteins that may be responsible for the net movement of BDE 47 out of the body. The continued development of a PBPK model will predict BDE 47 disposition across routes of exposure, dose, gender, and species. Risk estimates utilizing the toxicokinetic data generated in this study suggest that currently there is no margin of safety between BDE 47 exposure to human infants and developmental neurotoxicity observed in rodent studies.
机译：尽管BDE 47对全球生产和使用多溴二苯醚的贡献很小，但它是在环境样品和人体组织中发现的主要阻燃同类物。有限的毒理学研究表明，BDE 47是一种发育性生殖和神经毒素，也是一种内分泌干扰物。本文研究了暴露，剂量和对BDE 47风险评估所需的反应之间的联系。我们假设BDE 47是一种持久的，具有生物蓄积性的有毒化学物质，具有类似于其他多卤代芳烃的毒代动力学特性。为了检验此假设并提供对BDE 47的人类健康风险评估必不可少的信息：在小鼠中表征了BDE 47的基本毒代动力学参数，重复给药对BDE 47的处置和排泄以及BDE的处置和排泄的影响研究了发育模型中的47，研究了小鼠快速BDE 47排泄的机制，并比较了BDE同系物47、99、100和153的毒代动力学。在成年雌性小鼠中，BDE 47被很好地吸收，其分布由亲脂性决定，新陈代谢是消除的次要成分，终末全身半衰期为22天。重复暴露比单独暴露会导致更高的身体负担，因此证明了潜在的生物蓄积性。除了快速的尿排泄过程外，BDE 47与其他多卤代芳烃的毒代动力学性质相似。发育中动物的组织分布与成年动物相似。然而，由于降低了BDE 47的排泄能力，实际的年幼动物体内的浓度更高。为表征肾脏快速排泄的机制所做的一些努力导致活性转运蛋白的范围缩小，这可能是BDE 47净流出的原因。的身体。 PBPK模型的持续发展将预测BDE 47在接触途径，剂量，性别和物种之间的分布。利用这项研究中产生的毒物代谢动力学数据进行的风险估算表明，目前在啮齿类动物研究中观察到的BDE 47暴露于人类婴儿与发育性神经毒性之间没有安全界限。

著录项

  • 作者

    Staskal, Daniele Faye.;

  • 作者单位

    The University of North Carolina at Chapel Hill.;

  • 授予单位 The University of North Carolina at Chapel Hill.;
  • 学科 Health Sciences Toxicology.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 251 p.
  • 总页数 251
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 毒物学（毒理学）;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号