The joint acute toxicity effect of 2,2′,4,4′-tetra-BDE (BDE-47) and sodium perchlorate (PER) on adult zebrafish was analyzed under the Standard aquatic toxicity determination .The results indicated that BDE47 and PER were low toxicity substance and the combined effects of the two substances exist on adult zebrafish were synergy .The liver of adult zebrafish co-exposed to BDE47 and PER was collected for assaying superoxide dismutase ( SOD ) and catalase ( CAT ) activity.The results showed that the SOD and CAT activities of liver in the co-exposure groups were significantly higher than the single exposure group ,indicating BDE-47 and PER existed combined effect on oxidative stress induced to the liver of adult zebrafish .%采用标准水生生物毒性测定方法研究了2，2′，4，4′－四溴二苯醚（BDE－47）与高氯酸钠（PER）对斑马鱼的联合急性毒性效应。实验结果表明，BDE－47与PER均属于低毒物质，且两种物质对斑马鱼的急性毒性存在协同的联合作用。通过对复合暴露后鱼体肝脏超氧化歧化酶（ SOD）与过氧化氢酶（ CAT）活性的分析，结果显示，复合暴露导致斑马鱼肝脏SOD与CAT的活性较单一暴露组显著升高，说明BDE－47与PER在对斑马鱼肝脏氧化应激的诱导方面存在联合效应。
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