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Pre-harvest interventions for reducing Escherichia coli O157:H7 associated with market ready beef feedlot cattle.

机译：减少与市售牛肉饲养场牛相关的大肠杆菌O157：H7的收获前干预措施。

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摘要

Escherichia coli O157:H7 is an important foodborne pathogen and beef cattle represent important reservoirs. E. coli O157:H7 has caused important economic losses to the beef industry and can cause severe illness and death in humans. Pre-harvest interventions have been suggested as a tool to help reduce the occurrence of E. coli O157:H7 associated with beef feedlot cattle. Five clinical trials were conducted to evaluate the effects of Lactobacillus acidophilus strain NPC 747 or an experimental vaccine for reducing the occurrence of E. coli O157:H7 associated with market ready beef feedlot cattle. Feedlot cattle supplemented with 109 CFU daily of NPC 747 were 35% less likely to test positive for E. coli O157:H7 in feces. In an evaluation of dose response and herd immunity to a vaccine, cattle receiving 1, 2, or 3 doses of the vaccine were 68, 67, and 73% less likely to test positive for E. coli O157:H7 in feces compared with external controls. Additionally, vaccinated cattle may have conferred protection to unvaccinated cattle within the same pen, providing evidence for a herd immunity effect. In a second vaccine study, vaccine efficacy for cattle receiving 3 doses of the vaccine was 98.5% when evaluating colonization of E. coli O157:H7 in terminal rectum mucosa (TRM) samples. In two large-scale clinical trials pens of vaccinated cattle were less likely to test positive for E. coli O157:H7 using a novel sampling device (ROPES) and vaccine efficacy was calculated at 76.0% when evaluating colonization of E. coli O157:H7 in TRM samples. NPC 747 and vaccination had no adverse effects on the important feedlot performance outcomes of average daily gain, daily dry matter intake, and feed efficiency. These data support the use of pre-harvest interventions for controlling E. coli O157:H7 in market ready beef feedlot cattle.
机译：大肠杆菌O157：H7是重要的食源性病原体，肉牛是重要的水库。大肠杆菌O157：H7已给牛肉行业造成重大经济损失，并可能导致人类严重疾病和死亡。有人建议将收获前干预措施作为一种工具，以帮助减少与肉牛饲养场相关的大肠杆菌O157：H7的发生。进行了五个临床试验，以评估嗜酸乳杆菌NPC 747菌株或实验性疫苗对减少与现成牛肉饲养场牛相关的大肠杆菌O157：H7发生的影响。每天补充109 CFU NPC 747的饲养场牛粪便中大肠杆菌O157：H7呈阳性反应的可能性降低了35％。在评估疫苗的剂量反应和牛群免疫性时，与外部疫苗相比，接受1、2或3剂疫苗的牛粪便中大肠杆菌O157：H7呈阳性反应的可能性降低了68％，67％和73％控件。另外，在同一围栏内，接种牛可能对未接种牛具有保护作用，从而为牛群免疫效果提供了证据。在第二项疫苗研究中，当评估末端直肠粘膜（TRM）样品中的O157：H7大肠杆菌定植时，接受3剂疫苗的牛的疫苗效力为98.5％。在两项大规模的临床试验中，使用新型采样装置（ROPES），接种牛的猪的大肠杆菌O157：H7呈阳性反应的可能性较小，在评估大肠杆菌O157：H7的定殖时，疫苗效力计算为76.0％在TRM样本中。 NPC 747和接种疫苗对平均日增重，每日干物质摄入量和饲料效率的重要饲养场性能结果没有不利影响。这些数据支持使用收获前干预措施控制现成的牛肉饲养场牛中的大肠杆菌O157：H7。

著录项

  • 作者

    Peterson, Robert E.;

  • 作者单位

    The University of Nebraska - Lincoln.;

  • 授予单位 The University of Nebraska - Lincoln.;
  • 学科 Agriculture Animal Culture and Nutrition.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 205 p.
  • 总页数 205
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 饲料;
  • 关键词

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