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Occupational and Environmental Exposures, Genetic Polymorphisms and Bladder Cancer Risk among Male Farmers in Egypt.

机译：埃及男性农民的职业和环境接触，遗传多态性和膀胱癌风险。

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摘要

Objectives: To examine associations between bladder cancer risk and (1) farming as an occupation, (2) pesticide exposure, and (3) polymorphisms of the GSTM1, GSTT1, NQO1, and SOD2 genotypes among men farmers in Egypt, as well as (4) indirect exposure to farming among women living with a farmer.;Methods: We used questionnaire and genotype data from a multicenter case-control study in Egypt. Cases confirmed to have either urothelial carcinoma (UC) or squamous cell carcinoma (SCC), and frequency-matched population controls were included. Unconditional logistic and polytomous (where appropriate) regression models were used to estimate the odds ratios (OR) and 95% confidence intervals (CIs).;Results: Among the 1525 male cases confirmed as primary urinary bladder carcinomas and 2069 controls, we found that working as a farmer was significantly associated with increased bladder cancer risk for both smokers and non-smokers (AOR=1.72; 95% CI: 1.43-2.05, and AOR=3.46; 95% CI: 2.56-4.66, respectively) after adjustment for other known risk factors. To a lesser extent women living with farmers had increased odds of having bladder cancer (adjusted OR=1.33; 95% CI: 0.98-1.79).;Among the men farmers (cases=885 and controls=840), pesticide exposure was associated with increased risk of UC type of cancer (OR=1.28; 95% CI: 1.01-1.61) and the odds of having UC increased as the duration and frequency of exposure to pesticides increased. Furthermore, the highest risk was found among exposed farmers with genes encoding for moderate to low activity of the enzymes NQO1 and SOD2. There were no associations between the GSTT1 and GSTM1 null genotypes and bladder cancer risks among Egyptian farmers.;Conclusions: Our findings suggest that working as or living with a farmer is associated with increased bladder cancer risk in Egypt. Exposure to pesticides and polymorphisms of the NQO1 and SOD2 genotypes appear to be among the contributing risk factors.
机译：目的：研究膀胱癌风险与（1）以职业为农业，（2）接触农药以及（3）埃及男性农民中GSTM1，GSTT1，NQO1和SOD2基因型的多态性之间的关联，以及（ 4）与农民一起生活的妇女间接接触农业。方法：我们使用了来自埃及多中心病例对照研究的问卷和基因型数据。确认患有尿路上皮癌（UC）或鳞状细胞癌（SCC）的病例，并包括频率匹配的人群对照。结果：在1525例确诊为原发性膀胱癌的男性病例和2069例对照中，我们发现无条件logistic和多变量（酌情）回归模型可用于评估比值比（OR）和95％置信区间（CIs）。调整了吸烟者和非吸烟者后，吸烟者和非吸烟者患膀胱癌的风险显着相关（AOR = 1.72； 95％CI：1.43-2.05； AOR = 3.46； 95％CI：2.56-4.66）其他已知的危险因素。在较小的程度上，与农民居住的妇女罹患膀胱癌的几率增加（调整后的OR = 1.33； 95％CI：0.98-1.79）。；在男性农民中（病例= 885，对照组= 840），农药接触与UC患癌症的风险增加（OR = 1.28； 95％CI：1.01-1.61），并且UC的几率随着接触农药的时间和频率的增加而增加。此外，在暴露的农户中发现最高风险，这些农户的基因编码的酶NQO1和SOD2具有中等至低活性。埃及农民中GSTT1和GSTM1无效基因型与膀胱癌风险之间没有关联。结论：我们的发现表明，与农民一起工作或与农民一起生活与埃及膀胱癌风险增加相关。暴露于农药和NQO1和SOD2基因型的多态性似乎是造成危险的因素之一。

著录项

  • 作者

    Dawson, Rebecca Smullin.;

  • 作者单位

    University of Maryland, Baltimore.;

  • 授予单位 University of Maryland, Baltimore.;
  • 学科 Health Sciences Occupational Health and Safety.;Health Sciences Toxicology.;Health Sciences Epidemiology.
  • 学位 Ph.D.
  • 年度 2013
  • 页码 120 p.
  • 总页数 120
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 地球物理学;
  • 关键词

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