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首页> 外文学位 >The effect of long chain polyunsaturated fatty acids on bone throughout the lifespan: An investigation of bone mass and its regulation by bone and mineral metabolism.
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The effect of long chain polyunsaturated fatty acids on bone throughout the lifespan: An investigation of bone mass and its regulation by bone and mineral metabolism.

机译：长链多不饱和脂肪酸在整个生命周期中对骨骼的影响：骨骼质量及其对骨骼和矿物质代谢的调节作用的研究。

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摘要

The pathology of osteoporosis is low bone mass potentially leading to fractures. Dietary long chain polyunsaturated fatty acids (LCPUFA), including arachidonic acid (AA), eicosapenaenoic acid (EPA) and docosahexaenoic acid (DHA), influence bone mass, mineral content and metabolism. The amount of each of these LCPUFA required throughout the lifespan to optimize bone health is unknown. To further understand the effects of specific LCPUFA in infant bone growth, dietary AA and DHA in varying amounts at a 5:1 ratio were added to formula and fed to male piglets for 15 d. Bone mass, as measured by dual energy x-ray absorptiometry (DXA), was higher with 0.5 and 0.1 g/100 g of fat as AA and DHA than in the unsupplmented group. These effects were not explained by changes in bone (including tibia prostaglandin E2) or mineral metabolism. Higher amounts (1.0 g AA and 0.2 g DHA/100 g of fat) reduced bone resorption, altered femur Zn and Ca content, but did not affect bone mass. To assess whether other life stages were affected by specific LCPUFA, a long-term rat study was conducted. The effects of an EPA diet (0.5 g EPA, 0.1 g AA and 0.1 g DHA/100 g of fat) or an AA diet (0.5 g AA, 0.1 g EPA and 0.1 g DHA/100 g of fat), to reflect current recommendations and/or intakes, on bone mineral content (BMC) and area (BA) using DXA and femur morphometry were compared at 3 time points (early, mid and late) from weanling to maturity (over 49 wk) in male and female rats. Compared to control, dietary EPA, regardless of when supplemented, decreased femur BA in males and decreased urinary Ca in females. At the levels studied, neither AA nor EPA affected BMC, bone resorption or femur prostaglandin E2. Compared to control, males fed AA mid or continuously had wider femur neck and head widths, respectively. Femur Mg, Zn and P content, but not Ca, were altered by dietary AA and EPA. The effects on Zn and P content were gender specific. Dietary AA or EPA with DHA affect mineral metabolism and bone size or mass at different stages in the life cycle. Whether higher neonatal bone mass and elevated femur neck and head width during maturity offer protection against osteoporotic fracture requires clarification.
机译：骨质疏松症的病理是低骨量，可能导致骨折。饮食中的长链多不饱和脂肪酸（LCPUFA），包括花生四烯酸（AA），二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），会影响骨骼质量，矿物质含量和代谢。在整个生命周期中优化骨骼健康所需的每种LCPUFA的量均未知。为了进一步了解特定的LCPUFA对婴儿骨骼生长的影响，将不同数量的日粮AA和DHA以5：1的比例添加到配方奶粉中，并饲喂雄性仔猪15天。通过双能X射线吸收法（DXA）测得的骨量，以AA和DHA分别为0.5和0.1 g / 100 g脂肪，高于未补充组。骨骼（包括胫骨前列腺素E2）或矿物质代谢的变化无法解释这些影响。较高的含量（1.0 g AA和0.2 g DHA / 100 g脂肪）可减少骨吸收，改变股骨锌和钙含量，但不影响骨量。为了评估其他生命阶段是否受特定的LCPUFA影响，进行了一项长期大鼠研究。 EPA饮食（0.5 g EPA，0.1 g AA和0.1 g DHA / 100 g脂肪）或AA饮食（0.5 g AA，0.1 g EPA和0.1 g DHA / 100 g脂肪）对反射电流的影响在雄性和雌性大鼠从断奶到成熟的三个时间点（早，中，晚）（早期，中期和晚期）比较了建议和/或摄入量，使用DXA和股骨形态测量的骨矿物质含量（BMC）和面积（BA） 。与对照组相比，饮食EPA，无论何时补充，男性的股骨BA降低，女性的尿Ca降低。在所研究的水平上，AA和EPA均不影响BMC，骨吸收或股骨前列腺素E2。与对照组相比，AA饲喂AA的男性的股骨颈和头部宽度分别更宽。饮食中AA和EPA改变了股骨的Mg，Zn和P含量，但不改变Ca。对锌和磷含量的影响是性别特异性的。膳食AA或EPA与DHA会影响生命周期中不同阶段的矿物质代谢以及骨骼大小或质量。在成熟过程中，较高的新生儿骨骼质量和股骨颈和头部的宽度增加是否可提供抗骨质疏松性骨折的保护，尚需澄清。

著录项

  • 作者

    Mollard, Rebecca C.;

  • 作者单位

    University of Manitoba (Canada).;

  • 授予单位 University of Manitoba (Canada).;
  • 学科 Health Sciences Nutrition.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 272 p.
  • 总页数 272
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;
  • 关键词

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