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首页> 外文学位 >Freesurfer vs manual tracing: Detecting future cognitive decline in healthy older adults at-risk for Alzheimer's disease.
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Freesurfer vs manual tracing: Detecting future cognitive decline in healthy older adults at-risk for Alzheimer's disease.

机译：Freesurfer对比手动追踪：检测处于老年痴呆症危险中的健康老年人的未来认知能力下降。

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摘要

Alzheimer's disease (AD) is a neurodegenerative pathological process that is thought to begin years prior to observable symptom onset. The hippocampus appears to be particularly vulnerable to the underlying brain pathology of AD. Hippocampal volume is a sensitive measure in predicting conversion from mild cognitive impairment to AD, but less is known regarding the use of hippocampal volume in asymptomatic individuals at risk for AD who eventually decline. The inconsistent findings may, in part, be due to the chosen method of hippocampal segmentation. FreeSurfer (FS) and manual tracings (MT) are two common segmentation techniques that have unique costs and benefits. The present study directly compared hippocampal volumes generated by FS and MT in a longitudinal design assessing cognitively healthy elders, with varying degree of risk for AD, over a 4.5-year period. After 4.5 years, 15 participants demonstrated cognitive decline, while 45 remained stable. The results suggest FS consistently produced larger hippocampal volumes than MT, but neither method distinguished between groups at baseline. Longitudinally, individuals who declined experienced a more progressive pattern of atrophy compared to those who remained stable. These data suggest that hippocampal volume over time may be a useful variable in determining cognitive change over time, with the addition of other known risk factors, such as genetic risk. This study also suggests that in presymptomatic individuals, MT may not provide added benefit over the use of the more cost-effective FS.
机译：阿尔茨海默氏病（AD）是一种神经退行性病理过程，据认为是在可观察到的症状发作之前数年开始的。海马似乎特别容易受到AD潜在的脑部病理的影响。海马体积是预测轻度认知障碍向AD转化的敏感指标，但是对于无症状的有AD风险但最终会下降的无症状个体使用海马体积知之甚少。不一致的发现可能部分归因于所选的海马分割方法。 FreeSurfer（FS）和手动跟踪（MT）是两种常见的细分技术，具有独特的成本和收益。本研究在纵向设计中直接比较了FS和MT产生的海马体积，该设计评估了4.5年内认知健康的老年人（具有不同程度的AD风险）。 4.5年后，有15位参与者表现出认知能力下降，而45位保持稳定。结果表明，FS始终比MT产生更大的海马体积，但两种方法在基线时均无法区分。纵向上，与保持稳定的人相比，下降的人经历的萎缩模式更为渐进。这些数据表明，随着时间的推移，海马体积可能是确定随时间推移认知变化的有用变量，另外还包括其他已知的风险因素，例如遗传风险。这项研究还表明，在有症状的个体中，MT可能不会比使用更具成本效益的FS提供更多益处。

著录项

  • 作者

    Butts, Alissa M.;

  • 作者单位

    Marquette University.;

  • 授予单位 Marquette University.;
  • 学科 Psychology Clinical.;Health Sciences Radiology.;Biology Neuroscience.
  • 学位 Ph.D.
  • 年度 2013
  • 页码 139 p.
  • 总页数 139
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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