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Design, synthesis, and film formation of stimuli-responsive colloidal dispersions containing phospholipids.

机译：包含磷脂的刺激响应胶体分散体的设计，合成和成膜。

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摘要

These studies were undertaken to further understand the design of colloidal dispersions containing bio-active phospholipids (PL) as stabilizing agents and their stimuli-responsive behaviors during film formation. Methyl methacrylate (MMA) and n-butyl acrylate (nBA) dispersions were synthesized using anionic surfactants and PL, and the surface-responsiveness of coalesced films was monitored at the film-air (F-A) and film-substrate (F-S) interfaces after exposure to temperature, UV, pH, ionic strength, and enzymatic stimuli. Using spectroscopic molecular-level probes such as attenuated total reflectance (ATR) and internal reflection IR imaging (IRIRI), these studies show that structural features of PL and surfactants significantly affect stimuli-responsiveness of polymeric films. MMA/nBA homopolymer, blend, copolymer, and core-shell particle coalescence studies indicated that controlled permeability is influenced by particle composition and sodium dioctyl sulfosuccinate (SDOSS) mobility to the F-A interface is enhanced in response to temperature. Utilization of hydrogenated soybean phosphocholine (HSPC) as a co-surfactant with SDOSS resulted in bimodal p-MMA/nBA colloidal particles, and experiments showed that ionic interactions with HSPC inhibit SDOSS mobility. However, the controlled release of individual species is detected in the presence of Ca2+ ionic strength stimuli. Utilizing 1,2-bis(10,12-tricosadiynoyl)- sn-glycero-3-phosphocholine (DCPC), cocklebur-shape particle morphologies were obtained and using transmission electron microscopy (TEM), self-assembled tubules were detected at particle interfaces, but not in the presence of Ca 2+. At altered concentration levels of DCPC, surface localized ionic clusters (SLICs) composed of SDOSS and DCPC form at the F-A and F-S interfaces in response to temperature and ionic strength stimuli. Micelle formation of 1-myristoyl-2-hydroxy-sn-glycero-phosphocholine (MHPC) stabilizes unimodal p-MMA/nBA colloidal particles. Elevated temperatures and K + ionic stimuli generate SLICs in the form of lipid rafts at F-A interfaces, and IRIRI and atomic force microscopy (AFM) experiments revealed that the rafts consist of crystalline SDOSS and MHPC domains. In contrast, 1,2-dilauroyl- sn-glycero-3-phosphocholine (DLPC) assembles liposomes during colloidal dispersion synthesis. TEM data illustrated that hollow p-MMA/nBA particles form, capable of releasing DLPC during coalescence in response to temperature, pH, ionic strength, and enzymatic changes, and lipid raft formation may be systematically controlled at the F-A and F-S interfaces.
机译：进行这些研究是为了进一步理解包含生物活性磷脂（PL）作为稳定剂的胶体分散体的设计及其在成膜过程中的刺激响应行为。使用阴离子表面活性剂和PL合成甲基丙烯酸甲酯（MMA）和丙烯酸正丁酯（nBA）分散体，并在曝光后在膜-空气（FA）和膜-基材（FS）界面监控聚结膜的表面响应性温度，紫外线，pH，离子强度和酶促刺激。这些研究使用诸如全反射衰减（ATR）和内部反射红外成像（IRIRI）的光谱分子级探针，这些研究表明PL和表面活性剂的结构特征显着影响聚合物薄膜的刺激响应性。 MMA / nBA均聚物，共混物，共聚物和核-壳粒子的聚结研究表明，可控的渗透性受粒子组成的影响，二辛基磺基琥珀酸二辛酯（SDOSS）随温度的变化而迁移至F-A界面。氢化大豆磷胆碱（HSPC）与SDOSS的共表面活性剂的使用产生了双峰p-MMA / nBA胶体颗粒，并且实验表明与HSPC的离子相互作用抑制了SDOSS的迁移。但是，在存在Ca2 +离子强度刺激的情况下检测到单个物质的控释。利用1,2-双（10,12-三二十二碳酰）-sn-甘油-3-磷酸胆碱（DCPC），获得鸟蛤形颗粒形态，并使用透射电子显微镜（TEM），在颗粒界面检测到自组装的小管，但不存在Ca 2+。在变化的DCPC浓度水平下，响应温度和离子强度刺激，由SDOSS和DCPC组成的表面局部离子簇（SLIC）在F-A和F-S界面形成。 1-肉豆蔻基-2-羟基-sn-甘油磷酸胆碱（MHPC）的胶束形成稳定了单峰p-MMA / nBA胶体颗粒。高温和K +离子刺激会在F-A界面以脂质筏的形式生成SLIC，IRIRI和原子力显微镜（AFM）实验表明，筏由SDOSS和MHPC晶体域组成。相反，在胶体分散体合成过程中，1,2-二十二烷基-sn-甘油-3-磷酸胆碱（DLPC）组装脂质体。 TEM数据表明，形成的中空p-MMA / nBA颗粒能够在聚结期间响应温度，pH，离子强度和酶促变化释放DLPC，并且可以在F-A和F-S界面上系统控制脂质筏的形成。

著录项

  • 作者

    Lestage, David Jackson.;

  • 作者单位

    The University of Southern Mississippi.;

  • 授予单位 The University of Southern Mississippi.;
  • 学科 Engineering Materials Science.; Chemistry Biochemistry.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 229 p.
  • 总页数 229
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 工程材料学;生物化学;
  • 关键词

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