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Development of high-throughput and miniaturized mass spectrometers using miniature cylindrical ion trap analyzers.

机译：使用微型圆柱离子阱分析仪开发高通量和小型化质谱仪。

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摘要

Mass spectrometry, widely known for high sensitivity and specificity, has become a ubiquitous tool for making a wide variety of measurements in the physical sciences. The objectives of the projects described in this thesis are the development of novel ion trap mass spectrometers, in particular, using cylindrical ion trap mass analyzers, for application in fieldable analysis of chemical species present in air and in high-throughput, parallel sample analysis. Two new mass spectrometer systems were developed. The first, a multiple channel, high throughput mass spectrometer using a cylindrical ion trap array was constructed. The goal of such an instrument is to demonstrate the possibility of using a cylindrical ion trap array for the simultaneous analysis of multiple, independent sample streams. Two fully multiplexed ion analysis channels (sources, ion optics, ion traps, detectors) were housed in a single vacuum chamber and operated with a common set of control electronics. Details of the instrument's construction are given. The performance of the instrument was demonstrated using electrospray ionization sources and several different sample types, including small molecules, peptides, and proteins.; The second instrument described is a miniature, atmospheric pressure ionization, cylindrical ion trap mass spectrometer. Current mass spectrometers are large, expensive, and delicate pieces of equipment and are not intended to be used in the field. The in situ detection of analytes for pollution monitoring, explosives detection, chemical warfare agent detection, process monitoring, and many other applications is desirable. A complete description of the instrument's construction is given in chapter three. Initial data from the instrument operated with corona discharge ionization and electrospray ionization is presented.
机译：质谱法因其高灵敏度和特异性而广为人知，已成为在物理科学中进行各种测量的一种普遍使用的工具。本文所描述项目的目的是开发新型离子阱质谱仪，特别是使用圆柱形离子阱质谱仪，用于空气中化学物质的现场分析以及高通量平行样品分析。开发了两个新的质谱仪系统。首先，使用圆柱形离子阱阵列构建了多通道，高通量质谱仪。这种仪器的目的是证明使用圆柱形离子阱阵列同时分析多个独立样品流的可能性。两个完全多路复用的离子分析通道（离子源，离子光学器件，离子阱，检测器）位于一个真空室内，并使用一组通用的控制电子设备进行操作。给出了仪器构造的详细信息。使用电喷雾电离源和几种不同的样品类型（包括小分子，肽和蛋白质）证明了该仪器的性能。所描述的第二种仪器是微型大气压电离圆柱形离子阱质谱仪。当前的质谱仪是大型，昂贵和精致的设备，并不打算在该领域中使用。期望用于污染监测，爆炸物检测，化学战剂检测，过程监测以及许多其他应用的分析物的原位检测。第三章给出了仪器结构的完整说明。给出了使用电晕放电电离和电喷雾电离操作的仪器的初始数据。

著录项

  • 作者

    Laughlin, Brian Carl.;

  • 作者单位

    Purdue University.;

  • 授予单位 Purdue University.;
  • 学科 Chemistry Analytical.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 255 p.
  • 总页数 255
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

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