• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >An epidemiological model and description of the occurrence, severity and long-term characteristics of premature infants with bronchopulmonary dysplasia.
【24h】

An epidemiological model and description of the occurrence, severity and long-term characteristics of premature infants with bronchopulmonary dysplasia.

机译：支气管肺发育不良早产儿的流行病学模型和描述，发生情况，严重程度和长期特征。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The objectives of this thesis were to examine the occurrence of respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) following a preterm birth and to provide a detailed description of the neonatal characteristics and long-term outcomes of BPD subjects. Additional objectives were to examine the factors associated with the severity of BPD.;Associations between clinical factors and the outcomes of RDS and/or BPD were tested for significance using one-way analysis of variance or Mantel-Haenszel chi-square tests. Independent risk factors were identified by univariate analyses and included in a multivariate logistic regression analysis for the outcomes of RDS and/or BPD. Severity of BPD was studied using an ordinal multinomial logistic regression model and the presence of a trend across levels of disease severity for BPD (mild, moderate or severe) was assessed using regression analysis.;For each additional week of prematurity, the adjusted odds of BPD increased by 54 percent. For each point subtracted on the APGAR score at 1-minute, the adjusted odds for BPD increased by 16 percent. BPD was associated with the presence of patent ductus arteriosus, pneumothorax or neonatal pneumonia/sepsis with adjusted odds ratios of 3.5 (95% confidence interval: 2.1, 6.0), 9.4 (3.6, 24.8) and 1.9 (1.1, 3.2) respectively. Greater severity of BPD was associated with greater likelihood of hospital readmission during the first 2 years of life, and with lower lung function at a later age.;This work provides a detailed description of the neonatal characteristics of a cohort of all preterm infants admitted to the MCH between 1980 and 1992, as well as describing the factors associated with the development of RDS and BPD in this cohort. This thesis also described the long-term complications of prematurity including lung function impairment, and established a link between the initial severity of BPD and long-term lung function.;A chart review of all preterm infants admitted at the Montreal Children.s Hospital between 1980 and 1992 was performed to create a cohort composed of 1192 subjects; 322 of whom met the definition of BPD.
机译：本文的目的是检查早产后呼吸窘迫综合征（RDS）和支气管肺发育不良（BPD）的发生，并详细描述BPD受试者的新生儿特征和长期预后。其他目标是检查与BPD严重程度相关的因素。使用单向方差分析或Mantel-Haenszel卡方检验对临床因素与RDS和/或BPD结局之间的关联进行显着性检验。通过单因素分析确定独立的危险因素，并将其纳入RDS和/或BPD结果的多因素Logistic回归分析中。使用序数多项Logistic回归模型研究BPD的严重程度，并使用回归分析评估BPD疾病严重程度（轻度，中度或重度）水平趋势的存在;对于早产儿每增加一周，调整后的赔率BPD增加了54％。对于在1分钟时APGAR得分减去的每个点，BPD的调整后赔率增加了16％。 BPD与动脉导管未闭，气胸或新生儿肺炎/败血症的存在有关，调整后的优势比分别为3.5（95％置信区间：2.1、6.0），9.4（3.6、24.8）和1.9（1.1、3.2）。 BPD的严重程度越高，在出生后的头2年内住院的可能性就越大，并且在以后的年龄中肺功能降低。这项工作详细描述了所有入院的早产儿的新生儿特征。 1980年至1992年的妇幼保健，并描述了与该人群中RDS和BPD发生有关的因素。本论文还描述了早产的长期并发症，包括肺功能损害，并建立了BPD的严重程度与长期肺功能之间的联系。蒙特利尔儿童医​​院收治的所有早产婴儿的图表回顾进行了1980年和1992年的研究以创建一个由1192名受试者组成的队列；其中322位符合BPD的定义。

著录项

  • 作者

    Landry, Jennifer S.;

  • 作者单位

    McGill University (Canada).;

  • 授予单位 McGill University (Canada).;
  • 学科 Health Sciences Medicine and Surgery.;Health Sciences Epidemiology.
  • 学位 M.Sc.
  • 年度 2010
  • 页码 101 p.
  • 总页数 101
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号