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首页> 外文学位 >Efficacy of beta-Hydroxy-beta-methylbutyrate (HMB) in free acid gel on indirect markers of skeletal muscle damage.
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Efficacy of beta-Hydroxy-beta-methylbutyrate (HMB) in free acid gel on indirect markers of skeletal muscle damage.

机译：游离酸凝胶中β-羟基-β-甲基丁酸（HMB）对骨骼肌损伤的间接标志物的功效。

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摘要

HMB has recently become a popular dietary supplement used to promote exercise performance and skeletal muscle hypertrophy by many exercise enthusiasts. A lot of previous studies have found that HMB supplement is beneficial to reduce muscle damage and decrease protein catabolism, which leads to increased gains in muscle size and strength when associated with resistance exercise. However, it is very important to note that these studies have focused primarily on the effect of calcium-HMB (the conventional form of the supplement). A recent study have indicated that HMB consumed in free acid gel form produced earlier and greater peaks in plasma HMB and improved clearance of HMB from plasma compared with an equivalent dosage of calcium-HMB by examining whether HMB in free acid gel form will improve HMB availability to human tissues. This finding suggests greater bioavailability of HMB when ingested as a free acid in gel form. Therefore, the aim of the present study was to investigate the efficacy of a newly developed form of HMB (consumed as a gel form) in reducing indicators of muscle damage after a single bout eccentric resistance exercise.;Seventeen male and sixteen female volunteers were randomly assigned into 5 treatment groups by matching based on average peak force on dominant leg. The 5 treatment groups consisted of Placebo (one capsule placebo and one 3ml-syringe gel placebo); Pre-exercise Ca-HMB (1capsule containing 1 g calcium-HMB ingested 30 min prior to strength test); Pre-exercise Gel-HMB (3 mL free-acid gel containing 1 g HMB ingested 30 min prior to strength test); Pre + Post Ca-HMB (1 capsule containing 1 g calcium-HMB 30 min prior to strength test plus 3 daily doses for 4 days); Pre + Post Gel-HMB (3 ml free-acid gel containing 1 g HMB 30 min prior to strength test plus 3 daily doses for 4 days). In a double-blind design, all subjects completed eccentric exercise bout which aimed to induce delayed onset (24--96 hr later) muscle soreness. During the experimental period, the blood draw and following tests were repeated at 24 hr, 48 hr, 72 hr and 96 hr after performing the eccentric exercise protocol: soreness feelings scale, vital signs (blood pressure and heart rate), height, body mass, thigh circumference (both Legs) and isometric leg extension strength.;There was a reduction in isometric leg extension strength and an increase in muscle soreness, thigh circumference and serum indices of damage (CK and LDH) following eccentric exercise. However, no significant differences were observed in changes of muscle soreness, maximal isometric leg extension strength, serum CK, LDH and thigh circumference between any treatment contrast from immediately to 48 h and 48h to 96h after eccentric exercise.;Our findings suggest that there were no clear effects of HMB in free acid gel on indirect markers of muscle damage than either a placebo or calcium-HMB treatment following a single bout of eccentric exercise.
机译：HMB最近已成为一种流行的膳食补充剂，被许多运动爱好者用来提高运动表现和骨骼肌肥大。先前的许多研究发现，HMB补充剂有益于减少肌肉损伤并减少蛋白质分解代谢，从而在与阻力运动相关的情况下导致肌肉尺寸和力量的增加。但是，非常重要的一点是要注意，这些研究主要集中在钙-HMB（补充剂的常规形式）的作用上。最近的一项研究表明，通过检查游离酸凝胶形式的HMB是否会提高HMB的利用率，与同等剂量的钙-HMB相比，以游离酸凝胶形式消耗的HMB产生的时间更早，血浆HMB的峰更大，并且改善了HMB从血浆中的清除率。对人体组织。该发现表明当以游离酸形式以凝胶形式摄入时，HMB具有更高的生物利用度。因此，本研究的目的是研究一种新开发的HMB形式（以凝胶形式使用）在减少一次单次偏心抵抗运动后肌肉损伤指标方面的功效。;随机分为17名男性和16名女性志愿者根据优势腿上的平均峰值力量将其分为5个治疗组。 5个治疗组由安慰剂组成（1个胶囊安慰剂和1个3ml注射器凝胶安慰剂）。运动前Ca-HMB（在强度测试前30分钟摄入1粒含1 g HMB钙的胶囊）；运动前凝胶-HMB（在强度测试前30分钟摄入3 mL含1 g HMB的游离酸凝胶）； Ca-HMB前后（1粒胶囊，在力量测试前30分钟内含1 g HMB钙，外加3天每日剂量，共4天）；前+后凝胶HMB（3毫升游离酸凝胶，在力量测试前30分钟含1克HMB，外加3天内每日剂量，共4天）。在双盲设计中，所有受试者均完成了离心运动，目的是诱发延迟发作（24--96小时后）的肌肉酸痛。在实验期间，在执行离心运动协议后的24小时，48小时，72小时和96小时重复抽血和随后的测试：酸痛感，体重指数，生命体征（血压和心率），身高，体重，大腿周长（双腿）和等长腿伸展力量。；等距运动后，等长腿伸展力量降低，肌肉酸痛，大腿周长和血清损伤指数（CK和LDH）增加。然而，在偏心运动后立即至48 h和48 h至96 h的任何治疗对比之间，肌肉酸痛，最大等长伸腿力量，血清CK，LDH和大腿围的变化均未观察到显着差异。一次离心运动后，与安慰剂或钙-HMB治疗相比，游离酸凝胶中HMB对肌肉损伤的间接标志物没有明显作用。

著录项

  • 作者

    Xing, Jin.;

  • 作者单位

    Iowa State University.;

  • 授予单位 Iowa State University.;
  • 学科 Health Sciences Recreation.;Biology Physiology.
  • 学位 M.S.
  • 年度 2012
  • 页码 62 p.
  • 总页数 62
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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