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首页> 外文学位 >Relationships of body fat, retinal levels of lutein and zeaxanthin, and age-related maculopathy in the carotenoids in age-related eye disease study.
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Relationships of body fat, retinal levels of lutein and zeaxanthin, and age-related maculopathy in the carotenoids in age-related eye disease study.

机译：年龄相关性眼病研究中人体脂肪，叶黄素和玉米黄质的视网膜水平与类胡萝卜素中年龄相关性黄斑病变的关系。

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摘要

Obesity may increase risk for age-related maculopathy (ARM), a disease affecting central vision, by reducing retinal lutein and zeaxanthin, where these carotenoids could be protective. An epidemiological approach was taken to investigate the relationships of body fat, retinal levels of lutein and zeaxanthin, and ARM in women participating in the Carotenoids in Age-Related Eye Disease Study (CAREDS).; No significant associations were observed between body mass index (BMI), waist circumference (WC), and waist-hip ratio (WHR) and prevalent ARM. Higher BMI was related to higher odds for early ARM (non-significant). Relationships of BMI to ARM were consistent with previous population studies, but were less consistent with WC and WHR.; Two studies were next undertaken to understand estimates of retinal lutein and zeaxanthin, or macular pigment. The first study evaluated reliability and within-person variability of macular pigment optical density (MPOD) and comparability between right and left eyes. The second study identified and described the determinants of MPOD in the CAREDS sample. Results of these investigations guided subsequent analyses and interpretations of associations of body fat and ARM.; Women with high body fat had significantly lower MPOD compared to lean women. Associations were similar among all body fat measures; however, WC was the strongest correlate of MPOD. Levels of MPOD were also observed to be lower among women with high compared to low WC, regardless of dietary lutein and zeaxanthin intake.; The hypothesis that high levels of MPOD are associated with lower odds for ARM was not supported in CAREDS. High compared to low MPOD was associated with higher odds for all types of early ARM. The associations differed significantly between middle and older-aged women, suggesting potential biases. Limiting the analyses to women with likely unstable diets due to chronic disease history reversed the associations (non-significant) and was consistent with a protective role of MPOD for ARM.; Future studies are needed to investigate the degree to which body fat impacts carotenoid metabolism and distribution in the blood and tissues. The inconsistent associations of MPOD to ARM among age-groups support the need for prospective longitudinal studies.
机译：肥胖症可能会通过减少视网膜叶黄素和玉米黄质而增加年龄相关性黄斑病（ARM）的风险，这种疾病会影响中央视力，而这些类胡萝卜素可以起到保护作用。在年龄相关性眼病研究（CAREDS）中，采用流行病学方法研究了参与类胡萝卜素的女性体内脂肪，视网膜黄体素和玉米黄质水平以及ARM的关系。在体重指数（BMI），腰围（WC）和腰臀比（WHR）与普遍的ARM之间未观察到显着关联。较高的BMI与早期ARM（无统计学意义）的较高机率相关。 BMI与ARM的关系与以前的人群研究一致，但与WC和WHR不一致。接下来进行了两项研究，以了解视网膜叶黄素和玉米黄质或黄斑色素的估计值。第一项研究评估了黄斑色素光密度（MPOD）的可靠性和人内变异性以及左右眼之间的可比性。第二项研究确定并描述了CAREDS样品中MPOD的决定因素。这些调查的结果指导了人体脂肪和ARM关联的后续分析和解释。与瘦女性相比，高脂肪女性的MPOD明显降低。所有人体脂肪测量之间的关联相似。但是，WC是MPOD的最强关联。与低WC相比，高WC妇女的MPOD水平也较低，而与叶黄素和玉米黄质的饮食无关。 CAREDS不支持高MPOD与ARM可能性较低相关的假设。对于所有类型的早期ARM，MPOD高与低MPOD相关的可能性更高。中年和老年妇女之间的关联差异很大，表明潜在的偏见。将分析仅限于因慢性病史而可能饮食不稳定的妇女，可以逆转这种关联（无统计学意义），并与MPOD对ARM的保护作用相一致。需要进一步的研究来研究体内脂肪对类胡萝卜素代谢和血液及组织分布的影响程度。年龄组中MPOD与ARM的不一致关系支持对前瞻性纵向研究的需求。

著录项

  • 作者

    Larowe, Tara Lea.;

  • 作者单位

    The University of Wisconsin - Madison.;

  • 授予单位 The University of Wisconsin - Madison.;
  • 学科 Health Sciences Ophthalmology.; Health Sciences Nutrition.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 234 p.
  • 总页数 234
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;
  • 关键词

  • 入库时间 2022-08-17 11:42:49

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