• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Periodontal disease, bone loss, and anti-androgen therapy.
【24h】

Periodontal disease, bone loss, and anti-androgen therapy.

机译：牙周疾病，骨质流失和抗雄激素治疗。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Periodontitis is a multifactorial disease with microbial dental plaque as the etiological agent. The manifestation and progress of periodontitis is influenced by a wide variety of determinants and factors, including subject characteristics, social and behavioral factors, systemic factors, genetic factors, the microbial composition of dental plaque, and others. The pathogenesis of periodontal disease results in resorption of alveolar bone and loss of the attachment apparatus to the teeth. There is a biological potential that periodontal destruction may be influenced by systemic bone loss. Since alveolar bone loss is a prominent feature of periodontal disease, disturbances in bone mineral density (BMD), especially in the jaws, are suspected of being an aggravating factor in periodontal disease. In previously published research, the severity of osteoporosis may be related to tooth loss in post-menopausal women. Considering the relationship among bone mineral density, osteoporosis, and periodontitis in men, it is known that men completing androgen ablation therapy for control of prostate cancer are at higher risk for osteoporosis. As androgen deprivation therapy is the recommended treatment for men with metastatic or locally-advanced nonmetastatic prostate carcinoma, and as prostate carcinoma is the most common visceral malignancy and the second leading cause of death from cancer in men, the relationship between androgen deprivation therapy and loss of bone mineral density is a matter of public health importance.; This dissertation assesses the association between bone mineral density, the presence of periodontal disease, and the possible subsequent onset of clinical osteoporosis, as seen among a population of older women followed longitudinally; a set of men with prostate carcinoma undergoing androgen ablation therapy; and those men in the same set not receiving androgen ablation for prostate cancer. We believe our research, using the model of periodontal bone density and oral bone loss, shows additional clear empirical evidence pointing to a cause-and-effect relationship between androgen deprivation therapy and loss of bone mineral density.
机译：牙周炎是一种以微生物菌斑为病因的多因素疾病。牙周炎的表现和进展受多种决定因素和因素的影响，包括受试者的特征，社会和行为因素，系统性因素，遗传因素，牙菌斑的微生物组成等。牙周疾病的发病机制导致牙槽骨吸收和牙齿附着装置的丧失。牙周破坏有可能受到全身性骨丢失的生物学影响。由于牙槽骨丢失是牙周疾病的突出特征，因此怀疑骨矿物质密度（BMD）尤其是颌骨的紊乱是牙周疾病的加重因素。在先前发表的研究中，骨质疏松的严重程度可能与绝经后妇女的牙齿脱落有关。考虑到男性的骨矿物质密度，骨质疏松症和牙周炎之间的关系，众所周知，完成雄激素消融治疗以控制前列腺癌的男性患骨质疏松症的风险更高。由于雄激素剥夺疗法是转移性或局部晚期非转移性前列腺癌的男性的推荐治疗方法，而前列腺癌是最常见的内脏恶性肿瘤，也是男性死于癌症的第二大主要原因，因此，雄激素剥夺疗法与流失的关系骨矿物质密度的高低是公共卫生的重要问题。这篇论文评估了骨矿物质密度，牙周疾病的存在与随后可能发生的临床骨质疏松症之间的相关性，如纵向随访的老年妇女所见。一组接受雄激素消融治疗的前列腺癌男性；而同一组中的那些男性未因前列腺癌接受雄激素消融。我们相信，使用牙周骨密度和口腔骨丢失模型进行的研究显示出更多明确的经验证据，表明雄激素剥夺治疗与骨矿物质密度降低之间存在因果关系。

著录项

  • 作者

    Famili, Pouran.;

  • 作者单位

    University of Pittsburgh.;

  • 授予单位 University of Pittsburgh.;
  • 学科 Health Sciences Dentistry.; Health Sciences Public Health.; Health Sciences Medicine and Surgery.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 83 p.
  • 总页数 83
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 口腔科学;预防医学、卫生学;
  • 关键词

  • 入库时间 2022-08-17 11:42:52

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号