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The economic burden of opioid poisoning in the United States and determinants of increased costs in opioid poisoning.

机译：美国阿片类药物中毒的经济负担以及阿片类药物中毒成本增加的决定因素。

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摘要

Introduction: Opioid poisoning has been rapidly increasing in the past decade, and has been driven in large part due to increases in opioid prescribing. This has been accompanied by intervention efforts aimed at preventing and reversing opioid poisoning through naloxone prescription programs. Current literature have not quantified the economic burden of opioid poisoning. Understanding this information can help inform these efforts and bring light to this growing problem. In addition understanding various determinants of increased costs can help to identify the types of populations more likely to have greater costs.;Main Objectives: The objectives are 1) to quantify the economic burden of opioid poisoning, 2) to evaluate differences in costs, LOS, and in-hospital mortality depending on opioid type, 3) to identify opioids most likely to result in hospitalization for opioid-related ED visits and 4) to determine differences in the odds of admission to various hospital admission categories with respect to opioid type.;Methods: A cost-of-illness approach was used to estimate the economic burden of opioid poisoning. Direct costs and prevalence estimates were obtained from nationally representative databases. Other sources of direct costs were obtained from the literature. Indirect costs were measured using the human capital method. Differences in costs, LOS, and in-hospital mortality were measured through generalized linear models using the National Inpatient Sample in 2009 from the Healthcare Cost and Utilization Project. The Drug Abuse Warning Network database was used to evaluate opioids most likely to result in hospitalization and to evaluate the likelihood of different opioids to cause admission into different types of hospital settings.;Results: Opioid poisoning resulted in an economic burden approximately ;Conclusions: Opioid poisoning results in a significant economic burden to society. Costs, length of stay, in-patient mortality and the odds of hospitalization and admission type depend on the type of opioid involved. The results from this study can be used to inform policy efforts in providing interventions to reduce opioid poisoning and help focus efforts on populations at highest risk for increased costs.
机译：简介：在过去十年中，阿片类药物中毒一直在迅速增加，并且在很大程度上是由于阿片类药物处方的增加所致。这伴随着旨在通过纳洛酮处方计划预防和逆转阿片类药物中毒的干预措施。目前的文献还没有量化阿片类药物中毒的经济负担。了解此信息可以帮助指导这些工作，并为不断增长的问题提供启发。此外，了解成本增加的各种决定因素可以帮助识别更可能具有较高成本的人群类型。主要目标：目标是1）量化阿片类药物中毒的经济负担，2）评估成本差异，LOS ，以及取决于阿片类药物类型的院内死亡率，3）确定与阿片类药物相关的急诊就诊最有可能导致住院的阿片类药物，以及4）确定阿片类药物进入各种医院入院类别的几率差异。方法：采用疾病成本法估算阿片类药物中毒的经济负担。直接费用和患病率估计数是从具有国家代表性的数据库中获得的。其他直接成本来源也从文献中获得。间接成本是使用人力资本法计量的。费用，LOS和院内死亡率的差异是使用2009年“医疗保健成本和利用项目”中的“全国住院患者样本”通过广义线性模型测得的。药物滥用警告网络数据库用于评估最有可能导致住院的阿片类药物，并评估不同阿片类药物导致进入不同类型的医院环境的可能性。结果：阿片类药物中毒导致大约经济负担；结论：阿片类药物中毒给社会造成巨大的经济负担。费用，住院时间，住院死亡率以及住院和入院的几率取决于所使用的阿片类药物的类型。这项研究的结果可用于为减少阿片类药物中毒提供干预措施的政策努力提供参考，并有助于将努力集中于成本增加风险最高的人群。

著录项

  • 作者

    Inocencio, Timothy J.;

  • 作者单位

    Virginia Commonwealth University.;

  • 授予单位 Virginia Commonwealth University.;
  • 学科 Health Sciences Pharmacy.;Health Sciences Health Care Management.
  • 学位 Ph.D.
  • 年度 2012
  • 页码 213 p.
  • 总页数 213
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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