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A fluorescence microscopy study of quantum dots as fluorescent probes for brain tumor diagnosis.

机译：荧光显微镜研究量子点作为诊断脑肿瘤的荧光探针。

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In vivo fluorescent spectroscopy and imaging using endogenous and exogenous sources of contrast can provide new approaches for enhanced demarcation of brain tumor margins and infiltrations. Quantum dots (QDs) represent excellent contrast agents for biomedical imaging due to their broader excitation spectrum, narrower emission spectra, and higher sensitivity and stability. The epidermal growth factor receptors (EGFRs) are overexpressed in high-grade glioma patients and thus a potential target for brain tumor diagnosis. In this study, we conducted fluorescence microscopy studies of the up-take mechanism of the anti-EGFR conjugated QDs by human U87 and SKMG-3 glioblastoma cells. Our preliminary results show that QDs can enter into glioma cells through anti-EGFR mediated endocytosis, indicating that these nano-size particles can tag brain tumor cells. In addition, the success of labeling frozen brain tumor tissue specimens suggests the possibility for enhanced optical demarcation of brain tumors with QDs in vivo.

机译：使用内源性和外源性对比剂的体内荧光光谱和成像可以提供增强脑肿瘤边缘和浸润界限的新方法。量子点（QD）由于具有更宽的激发光谱，更窄的发射光谱以及更高的灵敏度和稳定性，因此代表了生物医学成像的出色对比剂。表皮生长因子受体（EGFRs）在高级别神经胶质瘤患者中过表达，因此是脑肿瘤诊断的潜在靶标。在这项研究中，我们进行了荧光显微镜研究人类U87和SKMG-3胶质母细胞瘤细胞摄取抗EGFR结合的QD的机制。我们的初步结果表明，量子点可以通过抗EGFR介导的内吞作用进入神经胶质瘤细胞，这表明这些纳米尺寸的颗粒可以标记脑肿瘤细胞。另外，标记冷冻的脑肿瘤组织标本的成功表明在体内用QD增强脑肿瘤的光学分界的可能性。

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作者
Wang, Jingjing.;
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作者单位

University of Southern California.;

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授予单位 University of Southern California.;
学科 Engineering Biomedical.
学位 M.S.
年度 2005
页码 45 p.
总页数 45
原文格式 PDF
正文语种 eng
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专利

1. Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis [J] . Jingjing Wang, William H. Yong, Yinghua Sun, Journal of biomedical optics . 2007,第4期

机译：受体靶向量子点：用于脑肿瘤诊断的荧光探针
2. Magnetically engineered Cd-free quantum dots as dual-modality probes for fluorescence/magnetic resonance imaging of tumors [J] . DingK., JingL., LiuC., Biomaterials . 2014,第5期

机译：磁性工程无镉量子点作为双模式探针，用于肿瘤的荧光/磁共振成像
3. Serine and histidine-functionalized graphene quantum dot with unique double fluorescence emission as a fluorescent probe for highly sensitive detection of carbendazim [J] . Li Ruiyi, Jiang Yanhong, Wang Qinsheng, Sensors and Actuators . 2021,第Sepa期

机译：丝氨酸和组氨酸官能化石墨烯量子点，具有独特的双荧光发射作为荧光探针，用于高敏感性检测碳纳西姆
4. A fluorescence microscopy study of quantum dots as fluorescent probes for brain tumor diagnosis [C] . Jingjing Wang, P. Thomas. Vernier, Yinghua Sun, Plasmonics in Biology and Medicine II; Progress in Biomedical Optics and Imaging; vol.6, no.18 . 2005

机译：量子点作为荧光探针用于脑肿瘤诊断的荧光显微镜研究
5. Quantum dot-fluorescent protein pairs as fluorescence resonance energy transfer probes [D] . Dennis, Allison Marie 2009

机译：量子点荧光蛋白对作为荧光共振能量转移探针
6. Comparative Study of Time-Resolved Fluorescent Nanobeads Quantum Dot Nanobeads and Quantum Dots as Labels in Fluorescence Immunochromatography for Detection of Aflatoxin B1 in Grains [O] . Xin Wang, Xuan Wu, Zhisong Lu, 2020

机译：时间分辨荧光纳米珠量子点纳米珠和量子点作为荧光免疫色谱法检测谷物中黄曲霉毒素B1标记的比较研究
7. Comparative Study of Time-Resolved Fluorescent Nanobeads, Quantum Dot Nanobeads and Quantum Dots as Labels in Fluorescence Immunochromatography for Detection of Aflatoxin B1 in Grains [O] . Xin Wang, Xuan Wu, Zhisong Lu, 2020

机译：将时间分辨荧光纳米珠，量子点纳米孔和量子点作为荧光免疫层状粒子标记的比较研究，用于检测晶粒黄曲霉毒素B1

A fluorescence microscopy study of quantum dots as fluorescent probes for brain tumor diagnosis.

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