• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >An Exploration of the Genetics and Molecular Mechanisms Underlying Conserved Longevity Interventions.
【24h】

An Exploration of the Genetics and Molecular Mechanisms Underlying Conserved Longevity Interventions.

机译：保守的长寿干预的遗传学和分子机制的探索。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aging is a degenerative process that causes a time-dependent deterioration of virtually every biological system in the majority of species. Age is the primary risk factor for many human diseases, including the top causes of death modern societies. Developing treatments to slow the aging process has the potential increase human life span and simultaneously prevent or improve outcomes in countless diseases. Studying aging in mammals is challenging due to the relatively high longevity of most mammalian species and the costs associated with maintaining populations of mammals in the laboratory for their entire life span. The invertebrate organisms Saccharomyces cerevisiae, Caenorhabditis elegans, and Drosophila melanogaster have emerged as central models in aging due to relatively short life spans, ease of maintenance in the laboratory, well characterized genetics, and the availability of a wide range of genetic and biochemical tools. By focusing on genetic pathways and interventions that influence longevity in a similar manner across these evolutionarily divergent species, we can gain insight into the biology of aging in mammals. The application of genome-scale techniques in aging research has started to define the range of genetic and environmental factors involved in longevity determination, and the high degree of intercommunication between these factors. This dissertation reviews current progress toward identifying and understanding conserved longevity interventions and presents several current lines of investigation aimed both at developing tools for analyzing the complex interactions between aging factors and at probing the mechanism of action of specific longevity interventions.
机译：衰老是一种退化过程，几乎导致大多数物种中每个生物系统的时间依赖性恶化。年龄是许多人类疾病的主要危险因素，包括现代社会死亡的主要原因。开发能够延缓衰老过程的疗法有可能延长人类寿命，同时预防或改善无数疾病的后果。由于大多数哺乳动物物种的相对较高的寿命以及与在整个生命周期中在实验室中维持哺乳动物种群有关的成本，研究哺乳动物的衰老具有挑战性。无脊椎动物，酿酒酵母，秀丽隐杆线虫和果蝇（Drosophila melanogaster）已成为衰老的主要模型，原因是寿命相对较短，实验室易于维护，遗传学特征明确以及可利用的多种遗传和生物化学工具。通过关注以类似方式影响这些进化差异物种的寿命的遗传途径和干预措施，我们可以深入了解哺乳动物衰老的生物学。基因组规模技术在衰老研究中的应用已开始确定寿命确定所涉及的遗传和环境因素的范围，以及这些因素之间的高度交流。本论文回顾了目前在识别和理解保守的长寿干预措施方面的进展，并提出了一些当前的研究方向，旨在开发用于分析衰老因素之间复杂相互作用的工具，并探讨特定长寿干预措施的作用机制。

著录项

  • 作者

    Sutphin, George L.;

  • 作者单位

    University of Washington.;

  • 授予单位 University of Washington.;
  • 学科 Aging.;Cellular biology.;Molecular biology.
  • 学位 Ph.D.
  • 年度 2012
  • 页码 219 p.
  • 总页数 219
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号