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Effects of caffeinated beverages on reproductive hormones in the biocycle study.

机译：在生物周期研究中，含咖啡因的饮料对生殖激素的影响。

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摘要

Caffeinated and fructose-rich beverages are widely consumed among women of reproductive age but their association with reproductive hormones is not well understood, due in part to inadequate exposure assessment. Our objectives were to 1) assess the relationship between caffeine and fructose intake and reproductive hormones in healthy premenopausal women, evaluating potential effect modification by race; and 2) determine the validity of the Food Frequency Questionnaire (FFQ) for measuring monthly caffeinated beverage intake compared to multiple 24-hour dietary recalls (24HDR). The BioCycle Study (2005--2007) prospective cohort (n=259) included women, ages 18--44, who were followed for 2 menstrual cycles, providing fasting blood specimens at up to 8 visits per cycle, 4 24HDRs per cycle, and an FFQ at the end of each cycle.;Caffeine intake ≥200 mg/day was inversely associated with free estradiol (E2) concentrations among white women (beta=-0.15 [95% confidence interval (CI): -0.26, -0.05] and positively associated among Asian women (beta=0.61 [95% CI: 0.31, 0.92] after taking into account potential confounders. Women who consumed more added sugar than an average American woman (≥ 73.2 grams/day) or above the 66th percentile in fructose intake (≥ 41.5 grams/day) had elevated free E2 concentrations compared to women who consumed less. Women who consumed ≥1 cup/day of sweetened soda had elevated free E2 (beta=0.15 [95% CI: 0.06, 0.24]. Neither artificially sweetened soda intake nor fruit juice intake ≥1 cup/day was significantly associated with reproductive hormones. Caffeine intake reported in the FFQ was greater than that reported in the 24HDRs (mean=114.1 versus 92.6 mg/day; P=0.006) despite high correlation (r=0.80, P0.001) and moderate agreement (kappa=0.56, 95% CI: 0.42--0.70).;In summary, moderate caffeine consumption was associated with reduced E2 among white women and elevated E2 among Asian women. Added sugars, total fructose, and sweetened soda were associated with elevated E2 among all races. Further research on the association between caffeine, caffeinated beverage components and reproductive hormones, and whether these relationships differ by race, is warranted. Additionally, although caffeine exposures are highly correlated, absolute intakes differ significantly between measurement tools, highlighting the importance of considering potential misclassification of caffeine exposure when conducting women's health epidemiologic studies.
机译：咖啡因和果糖含量高的饮料在育龄妇女中被广泛食用，但由于接触评估不足，人们对它们与生殖激素的关联尚不甚了解。我们的目标是：1）评估健康的绝经前妇女的咖啡因和果糖摄入与生殖激素之间的关系，评估种族对潜在影响的影响；和2）确定食物频率问卷（FFQ）用来衡量每月的含咖啡因饮料摄入量与24小时多次饮食召回（24HDR）相比的有效性。 《生物周期研究》（2005--2007年）的前瞻性队列研究（n = 259）包括年龄在18--44岁之间的女性，她们接受了2个月经周期的检查，每个周期最多提供8次就诊的空腹血液样本，每个周期提供4个24HDR， ；在每个周期结束时进行FFQ 。；咖啡因摄入量≥200 mg / day与白人女性中的游离雌二醇（E2）浓度呈负相关（β= -0.15 [95％置信区间（CI）：-0.26，-0.05 ），并与亚洲女性呈正相关（考虑到潜在的混杂因素后，β为0.61 [95％CI：0.31，0.92]。女性的糖摄入量高于平均水平（≥73.2克/天）或高于66％的美国女性与摄入较少的女性相比，摄入果糖的女性（≥41.5克/天）的游离E2浓度升高；每天摄入≥1杯甜苏打的女性的游离E2升高（β= 0.15 [95％CI：0.06，0.24] 。人工甜味汽水摄入量或果汁摄入量≥1杯/天均与生殖激素无显着相关。蒙尼斯。尽管相关性高（r = 0.80，P <0.001）和中度一致性（kappa = 0.56，95％），但FFQ中报告的咖啡因摄入量高于24HDR中报道的咖啡因摄入量（平均值= 114.1比92.6 mg /天; P = 0.006） CI：0.42--0.70）；总而言之，适度摄入咖啡因与白人妇女的E2降低和亚裔妇女的E2升高有关。在所有种族中，添加糖，总果糖和苏打糖与E2升高有关。有必要进一步研究咖啡因，含咖啡因的饮料成分和生殖激素之间的关系，以及这些关系是否因种族而异。此外，尽管咖啡因的摄入量高度相关，但绝对摄入量在两种测量工具之间却存在显着差异，这突出了进行妇女健康流行病学研究时考虑咖啡因暴露量可能分类错误的重要性。

著录项

  • 作者

    Schliep, Karen C.;

  • 作者单位

    The University of Utah.;

  • 授予单位 The University of Utah.;
  • 学科 Health Sciences Nutrition.;Health Sciences Epidemiology.;Health Sciences Public Health.
  • 学位 Ph.D.
  • 年度 2012
  • 页码 115 p.
  • 总页数 115
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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