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Identification and characterization of pufferfish, zebrafish, and chicken receptors for proglucagon-derived peptides.

机译：鉴定和表征河豚草素，斑马鱼和鸡胰高血糖素衍生肽的受体。

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The pufferfish and zebrafish genome encodes 4 genes that are similar to receptors for proglucagon-derived peptides. 2 receptors are identified as glucagon receptors, 1 as a GIP receptor, and 1 as a GLP-2 receptor. I was unable to identify receptor genes in pufferfish and zebrafish that is most closely related to the human GLP-1 receptor. The chicken genome contains 3 receptors for proglucagon-derived peptides: glucagon, GLP-1, and the GLP-2 receptors. The tissue distribution of the chicken GLP-2 and glucagon receptors parallel the tissue distribution of their mammalian counterpart and therefore, I believe that the chicken receptors may have similar functions to their mammalian homologues. I compared the amino acid residue sequences of my predicted receptors to known receptors for proglucagon-derived peptides and propose that the pufferfish and zebrafish receptors have a broad specificity and the chicken receptors have more narrow specificity that is similar to human receptors for proglucagon-derived peptides.

机译：河豚和斑马鱼的基因组编码4个基因，与胰高血糖素衍生肽的受体相似。 2个受体被鉴定为胰高血糖素受体，1个被鉴定为GIP受体，1个被鉴定为GLP-2受体。我无法识别河豚和斑马鱼中与人类GLP-1受体关系最密切的受体基因。鸡基因组包含胰高血糖素衍生肽的3种受体：胰高血糖素，GLP-1和GLP-2受体。鸡的GLP-2和胰高血糖素受体的组织分布与它们的哺乳动物对应物的组织分布平行，因此，我认为鸡的受体可能具有与其哺乳动物同源物相似的功能。我将我的预测受体的氨基酸残基序列与胰高血糖素衍生肽的已知受体进行了比较，并提出河豚和斑马鱼受体具有广泛的特异性，而鸡受体则具有更窄的特异性，类似于人对胰高血糖素衍生肽的受体。

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作者
Wong, Kenneth.;
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University of Toronto (Canada).;

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授予单位 University of Toronto (Canada).;
学科 Biology Molecular.
学位 M.Sc.
年度 2004
页码 231 p.
总页数 231
原文格式 PDF
正文语种 eng
中图分类
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Identification and characterization of pufferfish, zebrafish, and chicken receptors for proglucagon-derived peptides.

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