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Protective effect of peroxiredoxin 2 on oxidative stress induced beta-cell toxicity in the pancreatic beta-cell line MIN6.

机译：过氧化物酶2对氧化应激诱导的胰腺β细胞系MIN6的β细胞毒性的保护作用。

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Type 1 and type 2 diabetes are characterized by an excessive loss of insulin producing β-cells. β-cells are particularly susceptible to increased oxidative stress induced apoptosis due to low expression of major antioxidants. Peroxiredoxin-2 (PRDX2) belongs to a group of antioxidants with antiapoptotic roles. Preliminary data indicate PRDX2 is expressed in the β-cells. Endogenous PRDX2 in the β-cell line MIN6 is found to decrease under oxidative stress conditions. I hypothesize that PRDX2 has a role in protecting β-cells against oxidative stress induced apoptosis. Overexpression or knockdown strategies were used to examine the role of PRDX2 in insulin-secreting MIN6 cells treated with various stimuli (cytokines, palmitate, streptozotocin) to induce apoptosis. Results showed that PRDX2 overexpression decreased oxidative stress induced apoptosis markers and cell death indicators, whereas knockdown of PRDX2 exaggerated oxidative stress induced toxicity. These findings suggest that PRDX2 plays a protective role in pancreatic β-cells under oxidative stress conditions.

机译：1型和2型糖尿病的特征是胰岛素分泌β细胞大量流失。由于主要抗氧化剂的低表达，β细胞特别容易受到氧化应激诱导的细胞凋亡的影响。 Peroxiredoxin-2（PRDX2）属于具有抗凋亡作用的抗氧化剂。初步数据表明PRDX2在β细胞中表达。发现β细胞系MIN6中的内源PRDX2在氧化应激条件下减少。我推测PRDX2在保护β细胞免受氧化应激诱导的细胞凋亡中起作用。使用过表达或基因抑制策略来检查PRDX2在经过各种刺激（细胞因子，棕榈酸酯，链脲佐菌素）处理以诱导细胞凋亡的胰岛素分泌性MIN6细胞中的作用。结果表明PRDX2过表达降低了氧化应激诱导的细胞凋亡标志物和细胞死亡指标，而PRDX2的敲低则夸大了氧化应激诱导的毒性。这些发现表明PRDX2在氧化应激条件下在胰腺β细胞中起保护作用。

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作者
Zhao, Fang.;
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University of Toronto (Canada).;

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授予单位 University of Toronto (Canada).;
学科 Biology Physiology.
学位 M.Sc.
年度 2011
页码 81 p.
总页数 81
原文格式 PDF
正文语种 eng
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1. Nitric oxide induces apoptosis via Ca2+-dependent processes in the pancreatic beta-cell line MIN6. [J] . Nakata M, Maruyama I, Yada T, Cell Structure and Function . 1999,第6期

机译：一氧化氮通过胰腺β细胞系MIN6中的Ca2 +依赖性过程诱导凋亡。
2. Unraveling the molecular machinery that promotes pancreatic beta-cell dysfunction during oxidative stress: focus on "Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic beta-cells: evidence for regulation by Rac1". [J] . Jastroch M American Journal of Physiology . 2011,第1Parta2期

机译：解开促进氧化应激期间胰腺β细胞功能障碍的分子机械：专注于“吞噬细胞的NADPH氧化酶促进胰腺β细胞中细胞因子诱导的线粒体功能障碍：RAC1的调节证据”。
3. Carbonyl reductase 1 protects pancreatic beta-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity (vol 49, pg 1522, 2010) [J] . Rashid M. A., Lee Seonmin, Tak Eunyoung, Free Radical Biology and Medicine: The Official Journal of the Oxygen Society . 2018,第期

机译：羰基还原酶1保护胰腺β细胞免受葡萄酸毒性和葡糖醇毒性的氧化应激诱导的凋亡（Vol 49，PG 1522,12010）
4. Sub-toxic Arsenite Induces a Multi-component Protective Response against Oxidative Stress in Human Cells [C] . Yu Hu, Salem Chouchane, Michael Schuliga, International conference on arsenic exposure and health effects . 2001

机译：副毒性亚砷酸盐诱导人体细胞中氧化应激的多组分保护响应
5. Recovery of pancreatic beta-cells from nitric oxide-induced damage. [D] . Hughes, Katherine J. 2009

机译：从一氧化氮诱导的损伤中恢复胰腺β细胞。
6. Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction. [O] . H Kaneto, J Fujii, T Myint, 1996

机译：还原糖通过糖基化反应引起氧化应激从而触发胰腺β细胞的氧化修饰和细胞凋亡。
7. Protective mechanism(s) of anti-oxidants in pancreatic-islet beta-cells against glucose toxicity and oxidative stress [O] . 2011

机译：protective mechanism(s) of anti-oxidants in pancreatic-islet beta-cells against glucose toxicity and oxidative stress

Protective effect of peroxiredoxin 2 on oxidative stress induced beta-cell toxicity in the pancreatic beta-cell line MIN6.

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