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首页> 外文学位 >Development and application of gas chromatography assays for detection of environmental toxins and cerebrospinal fluid biomarkers.
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Development and application of gas chromatography assays for detection of environmental toxins and cerebrospinal fluid biomarkers.

机译：气相色谱法检测环境毒素和脑脊液生物标志物的开发和应用。

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摘要

The high incidence rate of amyotrophic lateral sclerosis (ALS) and Parkinson dementia complex (PDC) on Guam following World War II sparked great interest in identifying possible causes. Studies showing that there is no apparent viral cause or genetic pattern of disease resulted in an intense search for environmental contributors to this phenomenon. An unusual amino acid found in cycads, beta-methylaminoalanine (BMAA), has been the focus of numerous investigations and even after 50 years, its relevance in the development of PDC and Guam ALS is still questionable. Recent studies implicating BMAA as a trigger for neurodegeneration have re-ignited the "cycad hypothesis," although there is controversy surrounding this claim. BMAA reportedly accumulates in brain tissue, and this finding has been published in several journals. Two chapters of this work describe new and sensitive methods to test the theory of BMAA bioaccumulation.;In addition to probing human tissue for neurotoxins, this work also describes the current problem of metabolomics studies in human samples. Recent advances in comprehensive gas chromatography provide an interesting approach to more thoroughly study the human cerebral spinal fluid metabolome. An unbiased chemometric analysis has been applied to detect specific markers of neurodegeneration. To address the inherent problem of biological variation, longitudinal samples have been used for an in-progress study that looks at the effects of diet on cognitive function.
机译：第二次世界大战后，关岛的肌萎缩性侧索硬化症（ALS）和帕金森痴呆症（PDC）的高发率引起了人们对寻找可能原因的极大兴趣。研究表明，没有明显的病毒病因或疾病的遗传模式导致人们强烈寻找导致这种现象的环境因素。苏铁中发现的一种不寻常的氨基酸β-甲基氨基丙氨酸（BMAA）一直是众多研究的重点，即使在50年后，其与PDC和关岛ALS的发展相关性仍然值得怀疑。尽管有关这一说法存在争议，但最近有关BMAA引发神经退行性变的研究重新点燃了“苏铁科的假设”。据报道，BMAA会在脑组织中积聚，这一发现已在几本期刊上发表。这项工作的两章描述了测试BMAA生物蓄积理论的新方法和灵敏方法。除了探测人体组织中的神经毒素外，这项工作还描述了人体样品中代谢组学研究的当前问题。综合气相色谱的最新进展为更深入地研究人脑脊髓液代谢组提供了一种有趣的方法。无偏化学计量分析已应用于检测神经变性的特定标志物。为了解决生物变异的内在问题，纵向样本已用于正在进行的研究中，研究饮食对认知功能的影响。

著录项

  • 作者

    Snyder, Laura Rose.;

  • 作者单位

    University of Washington.;

  • 授予单位 University of Washington.;
  • 学科 Health Sciences Toxicology.;Health Sciences Pathology.;Chemistry Analytical.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 145 p.
  • 总页数 145
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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