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Garlic (Allium sativum) for horses: In vitro antibacterial activity and in vivo toxicity.

机译：马用大蒜（大蒜）：体外抗菌活性和体内毒性。

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摘要

Garlic, commonly used as a supplement in livestock feed, has demonstrated toxic effects in some species. A disk diffusion method was utilized to determine the minimum inhibitory concentration (MIC) of allyl mercaptan against Streptococcus equi in vitro. Subsequently, freeze-dried garlic was offered to 2 horses for 71 days in gradually increasing doses from 0.05 g/kg BW b.i.d. to maximum voluntary intake (0.25 g/kg BW b.i.d.). Jugular blood sampled weekly was analyzed for hematology, biochemistry and Heinz bodies. The in vitro study concluded that allyl mercaptan does not have appreciable antibiotic activity against S. equi as measured by MICs in excess of 8g/L. In vivo, daily garlic in excess of 0.2 g/kg b.i.d. resulted in reduced red blood cell count, total and corpuscular hemoglobin and haptoglobin. There was an increased incidence of Heinz bodies on erythrocytes, erythrocyte size and total and free bilirubin. Recovery was largely complete within 4 weeks.
机译：大蒜通常用作家畜饲料的补充剂，在某些物种中已显示出毒性作用。利用圆盘扩散法测定烯丙基硫醇对马链球菌的最小抑菌浓度（MIC）。随后，将冷冻干燥的大蒜从0.05 g / kg BW b.i.d逐渐增加的剂量提供给两匹马71天。达到最大自愿摄入量（每天体重0.25克/千克体重）。每周取样的颈静脉血进行血液学，生物化学和亨氏体分析。体外研究得出的结论是，烯丙硫醇对马链球菌的抗菌活性不超过8g / L。在体内，每日蒜超过0.2 g / kg b.i.d.导致减少的红细胞数量，总血红蛋白和血红蛋白和触珠蛋白减少。 Heinz体在红细胞，红细胞大小以及总胆红素和游离胆红素上的发生率增加。恢复在4周内基本完成。

著录项

  • 作者

    Pearson, Wendy.;

  • 作者单位

    University of Guelph (Canada).;

  • 授予单位 University of Guelph (Canada).;
  • 学科 Health Sciences Toxicology.; Agriculture Animal Culture and Nutrition.
  • 学位 M.Sc.
  • 年度 2004
  • 页码 120 p.
  • 总页数 120
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 毒物学（毒理学）;饲料;
  • 关键词

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