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Influence of pathogenic bacterial determinants on genome stability of exposed intestinal cells and of distal liver and spleen cells.

机译：致病性细菌决定因素对裸露的肠细胞以及末梢肝和脾细胞的基因组稳定性的影响。

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Most bacterial infections can be correlated to contamination of consumables such as food and water. Upon contamination, boil water advisories have been ordered to ensure water is safe to consume, despite the evidence that heat-killed bacteria can induce genomic instability of exposed (intestine) and distal cells (liver and spleen). We hypothesize that exposure to components of heat-killed Escherichia coli 0157:H7 will induce genomic instability within animal cells directly and indirectly exposed to these determinants. Mice were exposed to various components of dead bacteria such as DNA, RNA, protein or LPS as well as to whole heat-killed bacteria via drinking water. Here, we report that exposure to whole heat-killed bacteria and LPS resulted in significant alterations in the steady state RNA levels and in the levels of proteins involved in proliferation, DNA repair and DNA methylation. Exposure to whole heat-killed bacteria and their LPS components also leads to increased levels of DNA damage.

机译：大多数细菌感染可能与食品和水等消耗品的污染有关。受到污染后，尽管有证据表明热杀死的细菌会引起裸露的（肠）和远端细胞（肝脏和脾脏）的基因组不稳定，但仍建议使用沸水咨询以确保安全饮水。我们假设暴露于热灭活的大肠杆菌0157：H7的成分将直接或间接暴露于这些决定因素诱导动物细胞内的基因组不稳定。小鼠暴露于死亡细菌的各种成分，例如DNA，RNA，蛋白质或LPS，以及通过饮用水暴露于全部热杀死的细菌。在这里，我们报告说，暴露于完整的热灭活细菌和LPS会导致稳态RNA水平以及参与增殖，DNA修复和DNA甲基化的蛋白质水平发生重大变化。暴露于完整的热灭活细菌及其LPS成分也会导致DNA损伤水平增加。

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作者
Walz, Paul S.;
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University of Lethbridge (Canada).;

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授予单位 University of Lethbridge (Canada).;
学科 Biology Cell.
学位 M.Sc.
年度 2011
页码 132 p.
总页数 132
原文格式 PDF
正文语种 eng
中图分类
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1. The nuclear pore complex protein Elys is required for genome stability in mouse intestinal epithelial progenitor cells. [J] . Gao N, Davuluri G, Gong W, Gastroenterology . 2011,第5期

机译：核孔复合蛋白Elys是小鼠肠道上皮祖细胞中基因组稳定所必需的。
2. Pathogenic avian adenovirus type II induces apoptosis in turkey spleen cells. [J] . Rautenschlein S, Suresh M, Sharma JM Archives of virology . 2000,第8期

机译：II型致病性禽腺病毒诱导火鸡脾细胞凋亡。
3. Phenotype differences in spleen and liver T cells following injection with control or ethanol exposed precision cut liver slices (PCLS) [J] . J.R. Bowman, M.J. Duryee, C.D. Hunter, Alcohol . 2018,第期

机译：注射或乙醇暴露精密切割肝切片（PCLS）后脾脏和肝脏T细胞的表型差异（PCLS）
4. Melanomacrophage Centers in Kidney, Spleen and liver: A Toxic Response in Carp Fish (Cyprinus carpio) Exposed to Mercury Chloride [C] . Wahju Tjahjaningsih, Kustiawan Tri Pursetyo, Laksmi Sulmartiwi International Conference on Mathematics, Science, and Computer Science . 2017

机译：肾脏，脾脏和肝脏中的黑素肿手术中心：鲤鱼鱼（Cyprinus carpio）的毒性反应暴露于汞氯化物
5. Regulation of KCNQ1 potassium channels by vasoactive intestinal peptide in liver and colonic epithelial cells. [D] . Wehling, Erica R. 2007

机译：肝脏和结肠上皮细胞中血管活性肠肽对KCNQ1钾通道的调节。
6. Autoreactivity developing spontaneously in cultured mouse spleen cells. II. Comparison of cytotoxicity of cultured male and female spleen cells. [O] . R M Gorczynski 1976

机译：自反应在培养的小鼠脾细胞中自发发展。二。培养的男性和女性脾细胞的细胞毒性比较。
7. Cover Picture: The cover image features a frozen section from an embryonic day 16 mouse spleen stained by immunofluorescence to demonstrate the presence and location of lymphoid tissue inducer (LTi) cells. Witherset al. (pp. 3240–3245) show that these cells form the focus of lymphocyte accumulation in the developing mouse spleen. Red staining for CD45 marks haemopoietic cells, green shows IL-7Rα expression, and CD4 expression is in blue. LTi cells that express all markers (in white) cluster around blood vessels in the embryonic spleen where signalling to stromal cells initiates lymphocyte recruitment. – Eur. J. Immunol. 11/2007 [O] . David R. Withers, Mi-Yeon Kim, Vasileios Bekiaris, 2007

机译：封面图片：盖子图像具有来自免疫荧光染色的胚胎第16天小鼠脾脏的冷冻部分，以证明淋巴组织诱导症（LTI）细胞的存在和位置。靠近al。（第3240-3245页）表明，这些细胞在培养的小鼠脾脏中形成了淋巴细胞积累的焦点。 CD45的红色染色标记血液成对细胞，绿色显示IL-7Rα表达，CD4表达是蓝色的。 LTI细胞，其在胚胎脾脏周围表达血管周围的所有标记（白色）簇，其中信号传导到基质细胞引发淋巴细胞募集。 - 欧元。 J.Immunol。 11/2007
8. Mitogenic and Colony Forming Unit Responses of Spleen Cells from Mice Engrafted with Lewis Lung (3LL) Carcinoma Cells. [R] . Ledney, G. D., Moniot, J. V., Gambrill, M. R., 1976

机译：转染Lewis肺癌（3LL）癌细胞的小鼠脾细胞的有丝分裂和集落形成单位反应。

Influence of pathogenic bacterial determinants on genome stability of exposed intestinal cells and of distal liver and spleen cells.

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