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Motion-Correction in Spatial Frequency Domain Imaging; Optical Property Determination in Pigmented Lesions.

机译:空间频域成像中的运动校正;色素沉着病变的光学性质测定。

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摘要

Spatial-Frequency Domain Imaging (SFDI) is a non-contact wide-field optical imaging technology currently being used to study the optical properties and chromophore concentrations of in-vivo malignant melanomas and benign pigmented lesions. However, part of the challenge of developing a clinically deployable SFDI system is related to the development of strategies for effective compensation of subject motion, which in turn, is critical for recording high fidelity optical properties. The work below presents a two-part strategy for correcting subject motion within the context of SFDI data. After verifying the effectiveness of the technique by imaging tissue-simulating phantoms, a set of clinical skin-imaging studies was performed in order to compare the results of the adjusted processing method with data gathered from the current non-corrected method. Systematic characterization of the impact of motion variables on clinical SFDI measurements reveals that until SFDI instrumentation is developed to the point of instantaneous imaging, motion-compensation is necessary for measuring accurate optical properties of pigmented lesions in a clinical setting.
机译:空频域成像(SFDI)是一种非接触式广域光学成像技术,目前正用于研究体内恶性黑色素瘤和良性色素性病变的光学特性和生色团浓度。但是,开发可临床部署的SFDI系统的部分挑战与有效补偿对象运动的策略的开发有关,这反过来对于记录高保真度光学特性至关重要。下面的工作提出了一个两部分的策略,用于在SFDI数据的上下文中校正对象的运动。在通过对组织模拟体模进行成像验证了该技术的有效性之后,进行了一组临床皮肤成像研究,以便将调整后的处理方法的结果与从当前未校正的方法收集的数据进行比较。运动变量对临床SFDI测量值的影响的系统表征表明,直到SFDI仪器发展到瞬时成像点之前,运动补偿对于在临床环境中测量色素性病变的准确光学特性是必需的。

著录项

  • 作者

    Nguyen, John Quan Minh.;

  • 作者单位

    University of California, Irvine.;

  • 授予单位 University of California, Irvine.;
  • 学科 Biomedical engineering.
  • 学位 M.S.
  • 年度 2011
  • 页码 52 p.
  • 总页数 52
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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