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Three- and four-dimensional hemodynamics in human coronary artery segments.

机译：人冠状动脉节段的三维血流动力学。

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摘要

Intimal thickening is a normal response to low wall shear stress. Such thickening is a reaction to certain predispositions and can eventually develop into atherosclerotic plaque. Insights to such progression in coronary arteries are at present very limited. The reason for this is that coronary vessels are relatively small and tortuous and furthermore, this tortuosity complicates the ability to localize plaque positions with respect to vessel curvature, cardiac motion and pressure and flow changes. However it can be hypothesized that the localized shear stress distribution in 3-Dimensional (3-D), time-dependent coronary lumen morphology is related to regional atherosclerotic plaque severity.; With this hypothesis, and the incorporation of accurate 3-Dimensional geometries of the coronary vessel morphology, the aim of this study was to develop a computational fluid dynamic (CFD) analysis to describe local flow dynamics in both 3-D spatial and 4-D spatial and temporal domains from reconstructions of intravascular ultrasound (IVUS) and bi-plane angiographic fusion images. The CFD model developed was validated with many known flow studies and found to be in very close agreement. Flow conditions considered both steady and unsteady simulations as well as the analysis of human coronary vessel segments that incorporated arterial motion. Arterial hemodynamics was related to the severity of atherosclerotic plaque and vessel morphology. The incorporation of arterial motion was found to impact the axial velocity contour and wall shear stress distributions and hence may provide more realistic predictions on the progression and locations of atherosclerotic plaque.
机译：内膜增厚是对低壁切应力的正常反应。这种增厚是对某些易感性的反应，并最终可能发展成动脉粥样硬化斑块。目前对冠状动脉进展的见解非常有限。其原因是冠状动脉相对较小且曲折，此外，这种曲折使相对于血管曲率，心脏运动以及压力和流量变化的斑块位置定位能力变得复杂。然而，可以假设，三维（3-D），时间依赖性冠状动脉腔形态的局部切应力分布与区域动脉粥样硬化斑块的严重程度有关。以此假设为基础，并结合冠状动脉形态的精确3维几何形状，本研究的目的是开发一种计算流体动力学（CFD）分析，以描述3-D空间和4-D中的局部流动动力学。血管内超声（IVUS）和双平面血管造影融合图像重建的空间和时间域。所开发的CFD模型已通过许多已知的流量研究进行了验证，并且发现它们之间的一致性非常高。流动条件同时考虑了稳定和不稳定的模拟以及结合了动脉运动的人类冠状动脉节段的分析。动脉血流动力学与动脉粥样硬化斑块的严重程度和血管形态有关。发现动脉运动的合并会影响轴向速度轮廓和壁切应力分布，因此可能对动脉粥样硬化斑块的进展和位置提供更现实的预测。

著录项

  • 作者

    Ramaswamy, Sharan D.;

  • 作者单位

    The University of Iowa.;

  • 授予单位 The University of Iowa.;
  • 学科 Engineering Biomedical.
  • 学位 Ph.D.
  • 年度 2003
  • 页码 173 p.
  • 总页数 173
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
  • 关键词

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