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Polarization-sensitive Mueller-matrix optical coherence tomography.

机译：偏振敏感穆勒矩阵光学相干断层扫描。

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摘要

Measuring the Mueller matrix with optical coherence tomography (OCT) makes it possible to acquire the complete polarization properties of scattering media with three-dimensional spatial resolution. We first proved that the measured degree-of-polarization (DOP) of the backscattered light by OCT remains unity—a conclusion that validated the use of Jones calculus in OCT. A multi-channel Mueller-matrix OCT system was then built to measure the Jones-matrix, which can be transformed into a Mueller matrix, images of scattering biological tissues accurately with single depth scan. We showed that when diattenuation is negligible, the round-trip Jones matrix represents a linear retarder, which is the foundation of conventional PS-OCT, and can be calculated with a single incident polarization state although the one-way Jones matrix generally represents an elliptical retarder; otherwise, two incident polarization states are needed. We discovered the transpose symmetry in the roundtrip Jones matrix, which is critical for eliminating the arbitrary phase difference between the two measured Jones vectors corresponding to the two incident polarization states to yield the correct Jones matrix.; We investigated the various contrast mechanisms provided by Mueller-matrix OCT. Our OCT system for the first time offers simultaneously comprehensive polarization contrast mechanisms including the amplitude of birefringence, the orientation of birefringence, and the diattenuation in addition to the polarization-independent intensity contrast, all of which can be extracted from the measured Jones or the equivalent Mueller matrix. The experimental results obtained from rat skin samples, show that Mueller OCT provides complementary structural and functional information on biological samples and reveal that polarization contrast is more sensitive to thermal degeneration of biological tissues than amplitude-based contrast.; Finally, an optical-fiber-based multi-channel Mueller-matrix OCT was built and a new rigorous algorithm was developed to retrieve the calibrated polarization properties of a sample. For the first time to our knowledge, fiber-based polarization-sensitive OCT was dynamically calibrated to eliminate the polarization distortion caused by the single-mode optical fiber in the sample arm, thereby overcoming a key technical impediment to the application of optical fibers in this technology.
机译：用光学相干断层扫描（OCT）测量Mueller矩阵可以获取具有三维空间分辨率的散射介质的完整偏振特性。我们首先证明，OCT测得的反向散射光的偏振度（DOP）保持统一，这一结论验证了Jones演算在OCT中的使用。然后构建了多通道Mueller-matrix OCT系统，以测量Jones-matrix，该琼斯-matrix可以转换为Mueller矩阵，通过单次深度扫描即可准确地散射生物组织的图像。我们表明，当双衰减可忽略不计时，往返琼斯矩阵表示线性延迟器，这是常规PS-OCT的基础，并且尽管单向琼斯矩阵通常表示椭圆形，但可以用单入射偏振态进行计算。缓凝剂否则，需要两个入射偏振态。我们在往返琼斯矩阵中发现了转置对称性，这对于消除与两个入射偏振态相对应的两个测得的琼斯向量之间的任意相位差以产生正确的琼斯矩阵至关重要。我们研究了Mueller-matrix OCT提供的各种对比机制。除了与偏振无关的强度对比外，我们的OCT系统首次同时提供了全面的偏振对比机制，包括双折射的幅度，双折射的方向和双衰减，所有这些都可以从测得的琼斯或等效信号中提取。穆勒矩阵。从大鼠皮肤样本获得的实验结果表明，Mueller OCT在生物样本上提供了互补的结构和功能信息，并且表明偏振对比度比基于振幅的对比度对生物组织的热变性更敏感。最后，建立了基于光纤的多通道Mueller-matrix OCT，并开发了一种新的严格算法来检索样品的校准偏振特性。据我们所知，基于光纤的偏振敏感OCT进行了动态校准，以消除由样品臂中的单模光纤引起的偏振畸变，从而克服了光纤在此应用中的关键技术障碍。技术。

著录项

  • 作者

    Jiao, Shuliang.;

  • 作者单位

    Texas A&M University.;

  • 授予单位 Texas A&M University.;
  • 学科 Engineering Biomedical.; Physics Optics.
  • 学位 Ph.D.
  • 年度 2003
  • 页码 127 p.
  • 总页数 127
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;光学;
  • 关键词

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