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Active surveillance and incidence rate of dengue infection in a cohort of high risk population in Maracay, Venezuela.

机译：委内瑞拉马拉开的高危人群队列中的登革热感染的积极监测和发生率。

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摘要

In the absence of an effective vaccine, vector control and surveillance of dengue fever (DF) and dengue hemorrhagic fever (DHF) are the most important strategies currently used to reduce the impact of these diseases in affected population. The objectives of this study were to estimate the incidence of symptomatic and asymptomatic dengue cases, the prevalence of antidengue antibodies, and to evaluate the laboratory and clinical aspects related to an active surveillance of dengue cases. In this study, active surveillance was incorporated as a part of the study design. At total of 3,255 people from four high risk neighborhoods were followed in a two years prospective study whereby the participants' houses were visited three times a week. During these visits, dengue cases were characterized by identifying patients with fever as well as other symptoms that were compatible with dengue disease. In addition, a biannual blood sample was taken for each study participants, to establish the prevalence and six month incidence of dengue infection.;We found a crude incidence density (ID) of 3.24 by 100,000 person/days (p/d) which changed from 5.69 by 100,000 p/d for the first year of the study to 1.45 by 100.000 p/d in the second year. In both years, the months from July through September had the highest ID of 8.81 by 100,000 p/d. Children displayed higher ID when compared to adults, RR: 3.92 (2.38--6.48).;The Plaque Reduction Neutralization Test was used to assay for the presence of antidengue antibody in 2,125 study participants (65.3% of total). The prevalence of anti dengue antibodies was found to be 86.6% (1,840 positives). The prevalence of anti DENV-1 was 74%, while 65.2% of the participants had anti-DENV-1 and anti-DENV-2 simultaneously. The cumulative incidence of anti IgG dengue antibody in the negative participants (283 at the start of the study) was 30% in the first 6 months period, 29.6% in the second 6 months, and 23.8 in the third one.;The difference between the numbers of participants detected in the active surveillance, (270 confirmed and non confirmed dengue cases) with the numbers of people who showed sero-conversion to anti-IgG dengue antibody within a relatively short period of time suggested that there was a high number of asymptomatic dengue infections present in the population. Transmissibility of the virus, the surveillance of dengue, and vaccine implementation in the near future would all be affected by the large number of asymptomatic people in hyperendemic countries.;Keywords. Prevalence, asymptomatic, sero-conversion, antibodies, epidemic.
机译：在缺乏有效疫苗的情况下，媒介控制和登革热（DF）和登革出血热（DHF）的监测是目前用于减少这些疾病对受影响人群影响的最重要策略。这项研究的目的是评估有症状和无症状的登革热病例的发生率，抗登革热抗体的流行率，并评估与积极监测登革热病例有关的实验室和临床方面。在这项研究中，积极监测被纳入研究设计的一部分。在为期两年的前瞻性研究中，来自四个高风险社区的总计3255人得到了跟踪，该研究者每周对参与者的房屋进行三次访问。在这些访问期间，登革热病例的特征是确定发烧患者以及与登革热疾病相适应的其他症状。此外，每位研究参与者每两年采集一次血液样本，以确定登革热感染的患病率和六个月的发病率。我们发现，100,000人/天（p / d）的原始发病率密度（ID）为3.24从研究的第一年的5.69 x 100,000 p / d到第二年的1.45 x 100.000 p / d。在这两个年度中，从7月到9月的月份ID最高，为8.8十万人次，为8.81。与成人相比，儿童显示出更高的ID，RR：3.92（2.38--6.48）.;斑块减少中和测试用于分析2,125名研究参与者中抗登革热抗体的存在（占总数的65.3％）。发现抗登革热抗体的患病率为86.6％（1840阳性）。抗DENV-1的患病率为74％，而65.2％的参与者同时具有抗DENV-1和抗DENV-2。阴性参与者（研究开始时为283）的抗IgG登革热抗体的累积发生率在前6个月为30％，在后6个月为29.6％，在第3个月为23.8。主动监测中检测到的参与者数量（270例确诊和未确诊的登革热病例），以及在相对较短的时间内显示出抗IgG登革热抗体血清转化的人数，这表明人群中无症状的登革热感染。病毒的传播性，登革热的监测以及在不久的将来实施疫苗都将受到高流行国家大量无症状人群的影响。流行，无症状，血清转化，抗体，流行病。

著录项

  • 作者

    Espino, Carlos.;

  • 作者单位

    University of South Florida.;

  • 授予单位 University of South Florida.;
  • 学科 Health Sciences Public Health Education.;Health Sciences Public Health.;Health Sciences Epidemiology.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 151 p.
  • 总页数 151
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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