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首页> 外文学位 >An examination of the Index of Readiness as a predictor of adherence and an adherence intervention in HIV+ males who repeatedly failed anti-HIV treatment regimens (Immune deficiency).
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An examination of the Index of Readiness as a predictor of adherence and an adherence intervention in HIV+ males who repeatedly failed anti-HIV treatment regimens (Immune deficiency).

机译：检查准备指数是否可作为依从性的预测指标以及对反复失败的抗HIV治疗方案（免疫缺陷）的HIV +男性的依从性干预。

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摘要

Successful treatment of HIV infection requires the ability to sustain nearly perfect adherence to anti-HIV medications. Non-adherence to anti-HIV medications often results in drug resistance and treatment failure. In an effort to avoid drug resistance due to non-adherence, health care providers think that HIV+ individuals must be ready prior to initiating anti-HIV medications. Little research has been devoted to examining the relationship between readiness and HIV treatment adherence. In addition, HIV+ individuals who have repeatedly failed treatment have typically been omitted from adherence studies. The purposes of this quasi-experimental study were to examine the relationship between readiness and adherence to anti-HIV medications and to study the feasibility and effects of a multi-disciplinary adherence intervention entitled "STAR". Subjects were 19 previously medication-experienced HIV+ males beginning a new regimen of anti-HIV medications. The control group (n = 7) received the routine standard of care, while the intervention group (n = 12) received the STAR intervention. All subjects (n = 19) completed the Index of Readiness, an instrument measuring readiness, at the onset of the study. There was a statistically significant difference between those subjects reaching viral suppression (PCR 400) in the experimental group and those not reaching viral suppression in the control group at the end of the six-month study period. Subjects who experienced viral suppression had higher readiness scores with statistically significant higher scores on subscale 2 of the Index of Readiness, The effect sizes for all subscales and the total Index of Readiness scale scores were very sizable. Results from this study suggest that readiness may be a key component in successful adherence to anti-HIV treatment and that the Index of Readiness may predict the ability to adhere to anti-HIV medications. This study may also suggest that the STAR intervention is effective in enhancing adherence in HIV+ persons who have repeatedly failed previous anti-HIV treatment. Implications for future research include additional studies with larger samples to further examine the STAR intervention, to further explore the relationship between readiness and adherence, and to determine if the Index of Readiness predicts adherence to anti-HIV treatment.
机译：要成功治疗HIV感染，必须具备对抗HIV药物保持近乎完美的依从性的能力。不坚持使用抗HIV药物通常会导致耐药性和治疗失败。为了避免由于不坚持而引起的耐药性，医疗保健提供者认为，HIV +患者必须在开始使用抗HIV药物之前做好准备。很少有研究致力于检查准备情况与艾滋病毒治疗依从性之间的关系。此外，依从性研究通常会漏掉反复治疗失败的HIV +患者。这项准实验研究的目的是检验准备情况和坚持使用抗HIV药物之间的关系，并研究名为“ STAR”的多学科坚持治疗的可行性和效果。受试者为19位先前曾经历过药物治疗的HIV +男性，他们开始了一种新的抗HIV药物治疗方案。对照组（n = 7）接受常规护理标准，而干预组（n = 12）接受STAR干预。在研究开始时，所有受试者（n = 19）均已完成“准备就绪指数”（一种衡量准备状态的工具）。在六个月的研究期结束时，实验组中达到病毒抑制（PCR <400）的那些受试者与对照组中未达到病毒抑制的那些受试者之间在统计学上有显着差异。经历病毒抑制的受试者在就绪指数的次级量表2上具有较高的就绪评分，在统计学上具有较高的显着性得分。所有次级量表的效应量和总就绪指数量表得分均非常可观。这项研究的结果表明，准备就绪可能是成功坚持抗HIV治疗的关键因素，并且就绪指数可以预测坚持使用抗HIV药物的能力。这项研究还可能表明，STAR干预措施可以有效地增强先前抗HIV治疗反复失败的HIV +患者的依从性。对未来研究的意义包括对更大样本的其他研究，以进一步检查STAR干预措施，进一步探讨准备程度和依从性之间的关系，并确定“就绪指数”是否可预测抗HIV治疗的依从性。

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  • 作者

    Enriquez, Maithe.;

  • 作者单位

    University of Missouri - Kansas City.;

  • 授予单位 University of Missouri - Kansas City.;
  • 学科 Health Sciences Nursing.; Psychology Psychometrics.; Psychology Behavioral.
  • 学位 Ph.D.
  • 年度 2002
  • 页码 104 p.
  • 总页数 104
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;心理学研究方法;心理学;
  • 关键词

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