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首页> 外文期刊>AIDS >A single tablet regimen is associated with higher adherence and viral suppression than multiple tablet regimens in HIV+ homeless and marginally housed people.
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A single tablet regimen is associated with higher adherence and viral suppression than multiple tablet regimens in HIV+ homeless and marginally housed people.

机译：在HIV +无家可归者和边缘人群中，单药方案比多药方案具有更高的依从性和病毒抑制率。

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BACKGROUND: Although, single-tablet regimen (STR) efavirenz, emtricibine, and tenofovir disoproxil fumarate (EFV/FTC/TDF) may be appealing in HIV-infected persons who are at high risk for nonadherence, the degree to which this simplified formulation affects adherence is not known. The virologic effectiveness of this STR in a potentially nonadherent population remains a concern, given the rapid selection of drug resistance seen with these drugs. METHOD: We performed a prospective observational study assessing adherence and virologic response to EFV/FTC/TDF STR among a cohort of homeless and marginally housed individuals. We compared adherence and viral suppression to historical controls followed in the same cohort. RESULTS: Adherence was higher in EFV/FTC/TDF STR regimen compared to non-one-pill-once-daily therapy (P = 0.006) after controlling for multiple confounders. Viral suppression (HIV RNA <50 copies/ml) was greater in EFV/ FTC/TDF STR than non-one-pill-once-daily regimens (69.2 versus 46.5%; P = 0.02), but there was no difference in viral suppression after controlling for adherence. CONCLUSION: Once-daily EFV/TNF/FTC STR appears to be a reasonable option for individuals with multiple barriers to adherence. Randomized clinical trials addressing various therapeutic strategies for this patient population are needed.
机译：背景：尽管单药治疗方案（STR）依非韦伦，恩曲西滨和替诺福韦富马酸替诺福韦酯（EFV / FTC / TDF）可能对不依从性高风险的HIV感染者具有吸引力，但这种简化剂型的影响程度依从性未知。鉴于对这些药物所见耐药性的快速选择，这种STR在潜在非粘附人群中的病毒学有效性仍然值得关注。方法：我们进行了一项前瞻性观察性研究，评估了一群无家可归者和边缘居住者对EFV / FTC / TDF STR的依从性和病毒学应答。我们将依从和病毒抑制与同一队列中的历史对照进行了比较。结果：EFV / FTC / TDF STR方案在控制了多个混杂因素后，与非单次每日给药方案相比具有更高的依从性（P = 0.006）。 EFV / FTC / TDF STR中的病毒抑制作用（HIV RNA <50拷贝/ ml）大于非单剂一次方案（69.2对46.5％; P = 0.02），但病毒抑制作用无差异在控制依从性之后。结论：对于有多重依从性障碍的个体，每天一次的EFV / TNF / FTC STR似乎是一个合理的选择。需要针对该患者群体的各种治疗策略的随机临床试验。

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