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首页> 外文学位 >Cupular micromechanics and motion sensation in the toadfish vestibular semicircular canals.
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Cupular micromechanics and motion sensation in the toadfish vestibular semicircular canals.

机译：蟾蜍前庭半规管中的杯状微力学和运动感觉。

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摘要

The hydrodynamics of the semicircular canal generally acts to transform a head rotation acceleration stimulus into a cupula-level stimulus that follows head rotation velocity. Experimental measurement of the primary afferent response over the physiological range, however, reveals a diversity of neural responses. Some afferent responses follow the head rotation velocity and have a sensitivity that is unchanging with stimulus frequency. Other afferents have a response with less phase lag relative to acceleration and a sensitivity that increases with frequency. The source of this diversity in afferent response dynamics could lie in the micromechanics of the cupula or in post-mechano-transduction neural mechanisms. The goal of this work was to determine whether cupular micromechanics are a contributing source of unexplained afferent response behavior such as the diverse response dynamics during physiologically relevant stimuli, as well as unusual responses during pathological conditions. An experimental approach was used to shed light on the biomechanical role of the cupula in vestibular sensory transduction. The differential pressure across the cupula and the dilational pressure acting throughout the canal were measured using extremely sensitive custom-built pressure sensors. Fluorescent microsphere markers were used to track the displacement of the cupula. Measurement of dilational pressure did reveal that cupular deformations could underlie abnormal neural responses seen in some pathological conditions. The differential pressure response was found to vary between animals, but on average showed only a slight increase in sensitivity with frequency and was closely aligned with the phase of head rotation velocity. Cupula motion was found to follow head rotational velocity and had a flat frequency sensitivity, matching predictions of 1-D mathematical models for canal macromechanics. Preliminary work also found no significant variation in the displacement response with different locations on the cupula. From these results, it was concluded that cupular micromechanics are not a primary source of the diversity in afferent response dynamics during normal physiological conditions.
机译：半圆形管的流体动力学通常用于将头部旋转加速度刺激转换为跟随头部旋转速度的穹ula水平刺激。然而，在生理范围内对主要传入反应的实验测量揭示了神经反应的多样性。一些传入的响应跟随头部的旋转速度，并且其灵敏度随刺激频率而变化。其他传入的响应相对于加速度具有较小的相位滞后，并且灵敏度随频率而增加。传入反应动力学中这种多样性的原因可能在于吸盘的微力学或机械转导后的神经机制。这项工作的目的是确定杯状微力学是否是无法解释的传入反应行为的促成因素，例如生理相关刺激期间的各种反应动力学以及病理情况下的异常反应。一种实验方法被用来阐明在前庭感觉传导中的吸盘的生物力学作用。使用极其灵敏的定制压力传感器测量了跨过吸盘的压差和作用于整个根管的扩张压。使用荧光微球标记物来跟踪吸盘的位移。扩张压力的测量确实揭示了杯形变形可能是某些病理情况下所见异常神经反应的基础。发现动物之间的压差响应有所不同，但平均而言，灵敏度随频率仅略有增加，并且与头部旋转速度的相位紧密一致。发现穹ula运动跟随头部的旋转速度，并且具有平坦的频率敏感性，与用于运河宏观力学的一维数学模型的预测相匹配。初步工作还发现，在吸盘上不同位置的位移响应没有明显变化。从这些结果可以得出结论，杯状微力学并不是正常生理条件下传入反应动力学多样性的主要来源。

著录项

  • 作者

    Yamauchi, Angela Miwa.;

  • 作者单位

    The University of Utah.;

  • 授予单位 The University of Utah.;
  • 学科 Engineering Biomedical.; Biology Animal Physiology.; Biology Neuroscience.
  • 学位 Ph.D.
  • 年度 2002
  • 页码 111 p.
  • 总页数 111
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;生理学;神经科学;
  • 关键词

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