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Oral care intervention to alleviate chemotherapy-induced oral mucositis in children with cancer.

机译：口腔护理干预措施可减轻癌症儿童化疗引起的口腔粘膜炎。

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摘要

Treatment for childhood cancer has improved markedly in recent years. However, oral mucositis associated with high-dose and combination chemotherapy remains a common and extremely challenging childhood cancer treatment-related complication for oncology health professionals to manage.;The overall aim of these studies was to determine an effective regimen for oral care that would enable effective prevention and amelioration of chemotherapy-induced oral mucositis. The first study was focused on determining the clinical benefits of an oral care protocol for the prevention and reduction of chemotherapy-induced oral mucositis in children with cancer. The oral care protocol consisted of tooth brushing, 0.2% w/v (weight by volume) chlorhexidine gluconate mouthrinse and normal saline solution. The second study was designed to compare the efficacy of 0.2% w/v chlorhexidine gluconate and 0.15% w/v benzydamine hydrochloride, as a supplemental antimicrobial oral rinse agent in an oral care protocol for alleviating chemotherapy-induced oral mucositis for children with cancer.;In the first study 38.00% reduction in the incidence of ulcerative mucositis was found in children using the oral care protocol compared with children in the control group. The results also indicated that the severity of oral mucositis (p < 0.001) and the intensity of oral pain (p < 0.001) were significantly reduced for the oral care protocol group. The second study results indicated significant reduction of oral ulcerative lesions and the severity of oral mucositis (ps < 0.05) in children using the oral care protocol containing chlorhexidine compared with protocol containing benzydamine.;The main findings of significant differences in the incidence and severity of oral mucositis for pediatric patients receiving the oral care protocol in these studies were discussed in relationship to previous findings and in the context of oral care studies. The implications of the findings for nursing practice highlight the contribution oncology nurses can make to the clinical management of chemotherapy-induced oral mucositis of pediatric patients and the importance of further refinement of oral care protocol in future nursing research. (Abstract shortened by UMI.).
机译：近年来，儿童期癌症的治疗已有明显改善。然而，与大剂量联合化疗相关的口腔粘膜炎仍然是肿瘤学医疗专业人员要应对的常见且极具挑战性的儿童期癌症治疗相关并发症。这些研究的总体目的是确定一种有效的口腔护理方案，有效预防和改善化疗引起的口腔粘膜炎。第一项研究的重点是确定预防和减少癌症儿童化疗引起的口腔粘膜炎的口腔护理方案的临床益处。口腔护理方案包括刷牙，0.2％w / v（体积重量）葡萄糖酸洗必泰漱口水和生理盐水。第二项研究旨在比较0.2％w / v葡萄糖酸氯己定和0.15％w / v盐酸苯并丁胺作为口腔护理方案中补充抗菌口腔冲洗剂的疗效，以减轻癌症儿童的化学疗法诱发的口腔黏膜炎。 ；在第一项研究中，与对照组儿童相比，使用口腔护理方案的儿童发现溃疡性粘膜炎的发生率降低了38.00％。结果还表明，口腔护理方案组的口腔粘膜炎的严重程度（p <0.001）和口腔疼痛的强度（p <0.001）显着降低。第二项研究结果表明，与使用苯乙胺的方案相比，使用洗必泰的口腔护理方案的患儿口腔溃疡性病变和口腔粘膜炎的严重程度明显降低（ps <0.05）。在这些研究中，针对接受口腔护理方案的小儿患者的口腔粘膜炎，与以前的研究结果相关并在口腔护理研究的背景下进行了讨论。这些发现对护理实践的意义突显了肿瘤学护士对化疗引起的儿科患者口腔粘膜炎的临床管理的贡献，以及在今后的护理研究中进一步完善口腔护理方案的重要性。 （摘要由UMI缩短。）。

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  • 作者

    Cheng, Kin Fong.;

  • 作者单位

    The Chinese University of Hong Kong (Hong Kong).;

  • 授予单位 The Chinese University of Hong Kong (Hong Kong).;
  • 学科 Nursing.;Oncology.
  • 学位 Ph.D.
  • 年度 2002
  • 页码 305 p.
  • 总页数 305
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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