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Derivatization of small acids to enhance sensitivity in gas chromatography mass spectrometry and gas chromatography vacuum ultraviolet spectroscopy

机译：小酸的衍生化可提高气相色谱质谱法和气相色谱真空紫外光谱法的灵敏度

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摘要

Disinfection by-products (DBPs) are a significant concern in drinking water quality. Haloacetic acids, which are generated from disinfection processes, are one of the major groups in disinfection by-products. Because they induce potential harmful effects for human health, the US government has already established regulations to control the levels of haloacetic acids in drinking water. In order to control the presence of haloacetic acids in drinking water and monitor other potential harmful compounds, an appropriate analytical method is needed. In this study, a gas chromatography (GC) method was developed for detecting haloacetic acids in water. Three different derivatization reagents were compared for sensitivity enhancement in conjunction with mass spectrometry (MS) and vacuum ultraviolet (VUV) detection. A model study was first performed using acetic acid and then the study was extended to haloacetic acids. The sensitivity of GC-MS and GC-VUV had been increased after the derivatization. However, it also had many shortcomings and challenges that needed to be overcome: (1) the efficiency of derivatization was low; (2) the benzyl alcohol derivatization caused many side reactions in complex samples and generated high intensities of interference noises. Further study will need to modify the GC-MS and GC-VUV methods, especially for the detection of brominated trihaloacetic acids.
机译：消毒副产物（DBP）是饮用水质量中的重要问题。消毒过程中产生的卤乙酸是消毒副产物中的主要组之一。由于它们会危害人体健康，因此美国政府已经制定了法规来控制饮用水中的卤乙酸含量。为了控制饮用水中卤代乙酸的存在并监测其他潜在的有害化合物，需要一种适当的分析方法。在这项研究中，开发了一种气相色谱（GC）方法来检测水中的卤乙酸。结合质谱（MS）和真空紫外（VUV）检测，比较了三种不同的衍生试剂以提高灵敏度。首先使用乙酸进行模型研究，然后将研究范围扩展至卤乙酸。衍生化后，GC-MS和GC-VUV的灵敏度有所提高。但是，它也有许多缺点和挑战需要克服：（1）衍生化效率低； （2）苯甲醇的衍生化导致复杂样品中发生许多副反应，并产生高强度的干扰噪声。进一步的研究将需要修改GC-MS和GC-VUV方法，尤其是用于检测溴代三卤乙酸的方法。

著录项

  • 作者

    Wang, Chih-hao.;

  • 作者单位

    The University of Texas at Arlington.;

  • 授予单位 The University of Texas at Arlington.;
  • 学科 Analytical chemistry.
  • 学位 M.S.C.
  • 年度 2016
  • 页码 54 p.
  • 总页数 54
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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