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首页> 外文学位 >The Effects of Fish Oil Supplementation on Inflammation Markers in Chronic Kidney Disease Patients.
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The Effects of Fish Oil Supplementation on Inflammation Markers in Chronic Kidney Disease Patients.

机译：补充鱼油对慢性肾脏病患者炎症标志物的影响。

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摘要

The purpose of this study was to investigate the effects of the daily consumption of fish oil, containing 2.4g of n-3 fatty acids (1400 mg Eicosapentaenoic acid + 1000 mg Docosahexaenoic acid), on pro-inflammatory cytokines, IL-1beta, IL-6, and TNF-alpha for 8 weeks in CKD patients, stages 2-5. One prevalent characteristic of all stages of CKD is excessive production of these pro-inflammatory cytokines. Fish oil supplementation has been claimed to lower the levels of these pro-inflammatory cytokines, and as a result decrease the severity of inflammatory diseases. The benefits of fish oil supplementation for an extensive range of populations and a variety of health concerns are apparent, yet the anti-inflammatory benefits for stages 2-5 CKD patients are not as well documented. Consequently, continued studies in this area are clearly needed. Thirty-one individuals completed the current study, with 17 subjects in the fish oil group, while 14 subjects were included in the comparison group (safflower oil). Separate Repeated Measures ANOVAs were used to measure changes in the primary outcome variables using a 2 (fish oil or safflower oil) x 2 (time points) design. Significance level was set at p ≤ 0.05. The results of this study showed that fish oil supplementation does not decrease plasma pro-inflammatory markers TNF-alpha, IL-6, and IL-1 beta in CKD patients, stages 2-5. The analysis of TNF-alpha levels revealed no significant difference across time (p = 0.92) or between groups (p = 0.94). However, there was a group by time interaction, (p = 0.03). The analysis between IL-6 levels and treatment resulted in no significant difference across time (p = 0.30), between groups (p = 0.15), nor was there a significant group by time interaction with the trends across time differing by group membership (p = 0.82). Finally, the analysis between treatment and IL-1a resulted in no significant difference in IL-1beta levels across time (p = 0.17), between groups (p = 0.26) nor treatment-by-time interaction either (p = 0.44). The supplementation of fish oil was not found to decrease markers of inflammation, but did demonstrate that a short-term administration of fish oil is well-tolerated by CKD patients, stages 2-5. But, further investigation is essential to better define the long-term impact of fish oil supplementation in this high-risk population.
机译：这项研究的目的是调查每日食用含有2.4克n-3脂肪酸（1400毫克二十碳五烯酸+ 1000毫克二十二碳六烯酸）的鱼油对促炎细胞因子IL-1beta，IL的影响-6，CKD患者的TNF-α治疗8周（2-5期）。 CKD所有阶段的一个普遍特征是这些促炎细胞因子的过量产生。据称鱼油补充剂可降低这些促炎细胞因子的水平，从而降低炎性疾病的严重程度。鱼油补充剂对广泛的人群和各种健康问题的益处是显而易见的，但是对于2-5 CKD期患者的抗炎益处尚未得到充分的证明。因此，显然需要在这一领域继续研究。 31个人完成了本研究，鱼油组中有17名受试者，而比较组（红花油）中则包括14名受试者。单独的重复测量使用2（鱼油或红花油）x 2（时间点）设计，使用方差分析（ANOVA）来测量主要结果变量的变化。显着性水平设定为p≤0.05。这项研究的结果表明，鱼油补充剂不会降低CKD患者的血浆促炎性标志物TNF-α，IL-6和IL-1β（2-5期）。 TNF-α水平的分析显示，跨时间（p = 0.92）或组间（p = 0.94）没有显着差异。但是，存在按时间交互作用的组（p = 0.03）。 IL-6水平和治疗之间的分析结果显示，各组之间的时间差异无统计学意义（p = 0.30），各组之间的差异无统计学意义（p = 0.15）。 = 0.82）。最后，治疗与IL-1a之间的分析结果显示，各组间（-1 = 0.26）的IL-1β水平之间无显着性差异（p = 0.17），也没有发现治疗时相互作用（p = 0.44）。未发现补充鱼油可减轻炎症标志物，但确实证明了CKD患者在2-5期可以很好地耐受短期施用鱼油。但是，进一步调查对于更好地确定鱼油补充剂对这一高风险人群的长期影响至关重要。

著录项

  • 作者

    Deike, Erika.;

  • 作者单位

    Baylor University.;

  • 授予单位 Baylor University.;
  • 学科 Health Sciences Nutrition.;Health Sciences Immunology.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 122 p.
  • 总页数 122
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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