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The effect of immobilization on muscle function, peripheral activation, evoked contractile properties of the muscle, and muscle proteins in the blood after eccentric exercise.

机译:固定运动对离心运动后血液中肌肉功能,外周活化,诱发的肌肉收缩特性和血液中肌肉蛋白质的影响。

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摘要

The primary aim of this dissertation was to examine the role of short-term immobilization on muscle function recovery, excitability of the muscle, evoked contractile properties of the muscle, and muscle proteins in the blood after contraction-induced muscle injury. In Studies I and II, the effects of four days of immobilization on recovery of muscle function and serum creatine kinase (CK) activity after eccentric exercise was examined in 26 males, who were placed into one of three groups: immobilization, control, or light exercise. When the damaged elbow flexor muscles were immobilized or exercised for four consecutive days, force recovery over eight days was significantly enhanced compared to a control.;In Study II, during the four-day treatment period after eccentric exercise, immobilization resulted in a significant blunting of the CK response compared to the light exercise or control groups. However, increasing activity with light exercise did not have any effect on the CK response compared to control. The data from Study II suggested that reduced lymphatic transport with decreased muscular activity may have contributed to the lower CK response in the immobilized muscle.;In Study III, mechanisms to explain the observations in Studies I and II with immobilization were undertaken. Muscle excitability and evoked contractile properties of the muscle were examined to determine whether immobilization altered the mechanical properties of the muscle to favor an enhanced force response. After eccentric exercise, there were immediate and prolonged reductions in the evoked contractile properties of the muscle. Immobilization, however, had no effect on these measures.;CK and myoglobin were assessed during the four-day treatment period as well as during the five-day recovery period. There was a significant difference in the CK response between groups, with the immobilization demonstrating significant blunting of the CK response during the treatment period. Upon remobilization of the arm, CK activity increased but not as high as was anticipated. The myoglobin response, however, was not different between groups. Because their routes of entry into the blood differ, taken together, the myoglobin and CK response suggest that lymph transport likely contributed to the blunting of the CK response observed with immobilization.
机译:本论文的主要目的是研究短期固定化对肌肉功能恢复,肌肉的兴奋性,诱发的肌肉收缩特性以及收缩引起的肌肉损伤后血液中蛋白质的作用。在研究I和研究II中,对26名男性进行了为期4天的固定锻炼对偏心运动后肌肉功能恢复和血清肌酸激酶(CK)活性的影响,这些男性被分为以下三组之一:固定,对照或轻度行使。当连续四天固定或锻炼受损的肘屈肌时,与对照组相比,八天的力量恢复显着增强。在研究II中,偏心运动后的四天治疗期间,固定导致明显的钝化与轻度运动或对照组相比,CK反应的敏感性。然而,与对照相比,轻度运动增加活动对CK反应没有任何影响。研究II的数据表明,淋巴运输的减少和肌肉活动的减少可能是导致固定化肌肉中CK反应降低的原因。在研究III中,进行了解释研究I和II中固定化观察结果的机制。检查了肌肉的兴奋性和诱发的收缩特性,以确定固定是否改变了肌肉的机械特性,以增强力响应。进行离心运动后,立即引起的肌肉收缩特性迅速下降。但是,固定化对这些措施没有影响。在四天的治疗期间和五天的恢复期间评估了CK和肌红蛋白。两组之间的CK反应存在显着差异,固定化治疗期间CK反应明显减弱。手臂复位后,CK活性增加,但没有预期的高。但是,两组之间的肌红蛋白反应没有差异。由于它们进入血液的途径不同,加在一起,肌红蛋白和CK反应提示淋巴转运可能导致固定化观察到的CK反应钝化。

著录项

  • 作者

    Sayers, Stephen P.;

  • 作者单位

    University of Massachusetts Amherst.;

  • 授予单位 University of Massachusetts Amherst.;
  • 学科 Public health.;Kinesiology.;Animal Physiology.
  • 学位 Ph.D.
  • 年度 2001
  • 页码 376 p.
  • 总页数 376
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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