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首页> 外文学位 >Changes in serum lipids with change and fluctuation in body mass index and body fat distribution in Mexican Americans with type 2 diabetes.
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Changes in serum lipids with change and fluctuation in body mass index and body fat distribution in Mexican Americans with type 2 diabetes.

机译：墨西哥裔2型糖尿病患者血清脂质的变化与体重指数和身体脂肪分布的变化和波动之间的关系。

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摘要

This dissertation was written in the format of three journal articles. Paper 1 examined the influence of change and fluctuation in body mass index (BMI) over an eleven-year period, on changes in serum lipid levels (total, HDL, and LDL cholesterol, triglyceride) in a population of Mexican Americans with type 2 diabetes. Linear regression models containing initial lipid value, BMI and age, BMI change (slope of BMI), and BMI fluctuation (root mean square error) were used to investigate associations of these variables with change in lipids over time. Increasing BMI over time was associated with gains in total and LDL cholesterol and triglyceride levels in women. Fluctuation of BMI was not associated with detrimental lipid profiles. These effects were independent of age and were not statistically significant in men. In Mexican-American women with type 2 diabetes, weight reduction is likely to result in more favorable levels of total and LDL cholesterol and triglyceride, without concern for possible detrimental effects of weight fluctuation. Weight reduction may not be as effective in men, but does not appear to be harmful either.; Paper 2 examined the associations of upper and total body fat with total cholesterol, HDL and LDL cholesterol, and triglyceride levels in the same population. Multilevel analysis was used to predict serum lipid levels from total body fat (BMI and triceps skinfold) and upper body fat (subscapular skinfold), while controlling for the effects of sex, age and self-correlations across time. Body fat was not strikingly associated with trends in serum lipid levels. However, upper body fat was strongly associated with triglyceride levels. This suggests that loss of upper body fat may be more important than weight loss in management of the hypertriglyceridemia commonly seen in type 2 diabetes.; Paper 3 was a review of the literature reporting associations between weight fluctuation and lipid levels. Few studies have reported associations between weight fluctuation and total, LDL, and HDL cholesterol and triglyceride levels. The body of evidence to date suggests that weight fluctuation does not strongly influence levels of total, LDL and HDL cholesterol and triglyceride.
机译：本文以三篇期刊论文的形式撰写。论文1考察了11年期间体重指数（BMI）的变化和波动对2型糖尿病墨西哥裔人群血脂水平（总，HDL和LDL胆固醇，甘油三酸酯）变化的影响。使用包含初始脂质值，BMI和年龄，BMI变化（BMI斜率）和BMI波动（均方根误差）的线性回归模型来研究这些变量与脂质随时间变化的关联。随着时间的推移，BMI的增加与女性总胆固醇，LDL胆固醇和甘油三酸酯水平的增加有关。 BMI的波动与有害脂质谱无关。这些影响与年龄无关，在男性中无统计学意义。在患有2型糖尿病的墨西哥裔美国人中，减轻体重可能会导致总胆固醇和LDL胆固醇和甘油三酸酯的含量更有利，而无需担心体重波动可能产生的不利影响。减轻体重对男性可能不那么有效，但似乎也不有害。论文2检验了同一人群中上脂肪和总脂肪与总胆固醇，HDL和LDL胆固醇以及甘油三酸酯水平的关系。多级分析用于根据总体脂（BMI和肱三头肌皮褶）和上体脂肪（肩cap下皮褶）预测血清脂质水平，同时控制跨性别的性别，年龄和自我相关性的影响。体脂与血脂水平趋势没有显着相关。但是，上半身脂肪与甘油三酸酯水平密切相关。这表明，在控制2型糖尿病中常见的高甘油三酯血症中，上身脂肪的丢失可能比体重减轻更为重要。论文3是对体重波动与血脂水平之间相关性的文献综述。很少有研究报道体重波动与总胆固醇，低密度脂蛋白，高密度脂蛋白胆固醇和甘油三酸酯水平之间存在关联。迄今为止的证据表明，体重波动不会强烈影响总胆固醇，低密度脂蛋白和高密度脂蛋白胆固醇和甘油三酸酯的水平。

著录项

  • 作者

    Wear, Mary Louise.;

  • 作者单位

    The University of Texas Health Sciences Center at Houston School of Public Health.;

  • 授予单位 The University of Texas Health Sciences Center at Houston School of Public Health.;
  • 学科 Health Sciences Public Health.
  • 学位 Ph.D.
  • 年度 2001
  • 页码 104 p.
  • 总页数 104
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;
  • 关键词

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