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首页> 外文学位 >Development of a chemical means to mimic nucleo-cytoplasmic transport and catalytic reduction of secondary alkyl monohalides by cobalt(I) salen and nickel(I) salen electrogenerated at vitreous carbon electrodes.
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Development of a chemical means to mimic nucleo-cytoplasmic transport and catalytic reduction of secondary alkyl monohalides by cobalt(I) salen and nickel(I) salen electrogenerated at vitreous carbon electrodes.

机译：通过玻璃碳电极上电生成的钴（I）沙伦和镍（I）沙伦，模拟核细胞质运输和催化还原仲烷基单卤化物的化学方法的开发。

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摘要

Polymer chemistry has spawned many modern-day materials that have found utility in nearly all aspects of life. One aspect of importance to analytical and material chemists is how polymers in the form of hydrogels may selectively respond to their chemical environment for the purpose of detection or purification. Much work has been done on the development of responsive hydrogels, and recently a focus has been placed on incorporating biological motifs into abiotic hydrogels for the use of highly selective molecular recognition. The work herein describes how a hydrogel derived from protein found the nuclear pore complex (NPC) was characterized and subsequently mimicked on a synthetic platform.;The first half of this document provides an introduction to the field of responsive hydrogels and discusses how one aspect of the Nsp1 hydrogel was characterized. Specifically, attention is given to the measurement of diffusional processes of nuclear transport receptor (NTRs) with the Nsp1 hydrogel and how these compare to other macromolecular diffusional processes in additional, chemically inert hydrogels. These processes were measured by means of spatial frequency analysis of fluorescence recovery after photobleaching data obtained by confocal microscopy.;Later chapters focus on how an abiotic analog of the NPC was created. Briefly, moieties critical for selective transport within Nsp1 hydrogels were synthesized and grafted on a polyacrylamide backbone. Confocal microscopy was then utilized to determine the selectivity of the modified polyacrylamide gel. Lastly, characteristics of polyacrylamide gels and Nsp1 gels were compared.;In the final chapter, a divergence is made from the study of the nuclear pore complex and a discussion of the catalytic reduction of cyclohexyl monohalides by electrogenerated cobalt(I) salen and nickel(I) salen. Mechanistic aspects of the catalytic reduction of cyclohexyl halides by cobalt(I) are also discussed.
机译：高分子化学催生了许多现代材料，这些材料几乎可以应用于生活的各个方面。对于分析和材料化学家而言，重要的一个方面是水凝胶形式的聚合物如何可以选择性地响应其化学环境以进行检测或纯化。在响应性水凝胶的开发方面已经进行了许多工作，近来的焦点已集中在将生物基序整合到非生物水凝胶中，以用于高度选择性的分子识别。本文的工作描述了如何表征源自蛋白质的水凝胶并发现其随后被模拟在合成平台上的核孔复合物（NPC）.;该文件的前半部分对响应水凝胶领域进行了介绍，并讨论了反应水凝胶的一个方面表征了Nsp1水凝胶。具体来说，应注意Nsp1水凝胶对核转运受体（NTR）扩散过程的测量，以及与其他大分子化学惰性水凝胶中其他大分子扩散过程的比较。通过共聚焦显微镜获得的光致漂白数据后的荧光回收率的空间频率分析，对这些过程进行了测量。以后的章节重点介绍了如何创建NPC的非生物类似物。简而言之，合成了对Nsp1水凝胶内选择性转运至关重要的部分，并将其接枝在聚丙烯酰胺主链上。然后利用共聚焦显微镜确定改性聚丙烯酰胺凝胶的选择性。最后，比较了聚丙烯酰胺凝胶和Nsp1凝胶的特性。;在最后一章中，对核孔复合物的研究以及电生钴（I）塞伦和镍（N）我）萨伦。还讨论了钴（I）催化还原环己基卤化物的机理。

著录项

  • 作者

    Bird, Sean Patrick.;

  • 作者单位

    Indiana University.;

  • 授予单位 Indiana University.;
  • 学科 Analytical chemistry.
  • 学位 Ph.D.
  • 年度 2016
  • 页码 201 p.
  • 总页数 201
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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