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Applying coherence analysis to diffuse optical tomography studies using near infrared light in healthy adults.

机译:将相干分析应用于健康成年人中使用近红外光的漫射光学层析成像研究。

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摘要

Optical imaging is a relatively novel technique, in which infra-red light is used to investigate oxygenation of blood vessels in the brain. In response to increased neural activity, there is an increase in oxyhemoglobin concentration and a decrease in deoxyhemoglobin concentration. Since oxy- and deoxyhemoglobin have characteristic light absorption spectra, these changes can be determined by measuring attenuation of light at 830 nm and 690 nm. Hence optical imaging is capable of indirectly measuring levels of brain activity. Coherence analysis can determine brain regions whose activities are synchronous, as a means of determining functionally connected brain regions. This has not been investigated to date with optical imaging. In this thesis, I develop a novel coherence analysis technique in application to optical data, and show that this technique is both feasible and applicable to both healthy and patient populations.
机译:光学成像是一种相对新颖的技术,其中红外光用于研究大脑血管的氧合。响应于增加的神经活动,氧合血红蛋白浓度增加而脱氧血红蛋白浓度降低。由于氧合和脱氧血红蛋白具有特征性的光吸收光谱,因此可以通过测量830 nm和690 nm处的光衰减来确定这些变化。因此,光学成像能够间接测量大脑活动水平。相干分析可以确定活动同步的大脑区域,作为确定功能连接的大脑区域的一种手段。迄今为止,光学成像尚未对此进行研究。在本文中,我开发了一种新的相干分析技术,应用于光学数据,并表明该技术既可行又适用于健康人群和患者人群。

著录项

  • 作者

    Liapounova, Natalia.;

  • 作者单位

    University of Calgary (Canada).;

  • 授予单位 University of Calgary (Canada).;
  • 学科 Biology Neuroscience.;Physics Optics.;Health Sciences Radiology.
  • 学位 M.Sc.
  • 年度 2009
  • 页码 181 p.
  • 总页数 181
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;预防医学、卫生学;光学;
  • 关键词

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