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Nano/micro/meso scale interactions in mechanics of pharmaceutical solid dosage forms.

机译：药物固体剂型力学中的纳米/微米/介观尺度相互作用。

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摘要

Oral administration in form tablets has been the most common method for delivering drug to the human systemic blood circulation accurately and reproducibly due to its established manufacturing methods and reliability as well as cost. The mechanical criteria for a successful powder-to-tablet processing are good flowability, compressibility and compactibility that are closely related to the mechanical and adhesion properties of the particles and particle strength. In this thesis, air-coupled acoustic and ultrasonic techniques are presented and demonstrated as noncontact and nondestructive methods for physical (mechanical) integrity monitoring and mechanical characterization of tablets. A testing and characterization experimental platform for defect detection, coating thickness and mechanical property determination of tablets was also developed. The presented air-coupled technique was based on the analysis of the transient vibrational responses of a tablet in both temporal and spectral domains. The contact ultrasonic technique was based on the analysis of the propagation speed of an acoustic pulse launched into a tablet and its reflection from the coat-core interface of the tablet. In defect monitoring, the ultimate objective is to separate defective tablets from nominal ones. In the case of characterization, to extract the coating layer thicknesses and mechanical properties of the tablets from a subset of the measured resonance frequencies, an iterative computational procedure was demonstrated. In the compaction monitoring experiments, an instrumented punch and a cylindrical die were employed to extract the elasticity properties of tablets during compaction. To study the effect of compaction kinetics on tablet properties and defect, finite element analyses of single layer and bilayer tablets were performed. A noncontact work-of-adhesion technique was also demonstrated to determine the work-of-adhesion of pharmaceutical powder particles.
机译：由于其既定的制造方法，可靠性以及成本，以片剂形式口服给药已成为将药物准确，可重复地输送到人体全身血液循环的最常用方法。成功的粉剂-片剂加工的机械标准是良好的流动性，可压缩性和可压实性，与颗粒的机械和粘合性能以及颗粒强度密切相关。在本文中，空气耦合声学和超声技术作为平板电脑的物理（机械）完整性监测和机械表征的非接触式和非破坏性方法被提出和证明。还开发了用于缺陷检测，包衣厚度和片剂力学性能测定的测试和表征实验平台。提出的空气耦合技术是基于对平板电脑在时域和频谱域的瞬态振动响应的分析。接触超声技术基于对发射到片剂中的声脉冲的传播速度及其从片剂的衣芯界面的反射的分析。在缺陷监控中，最终目标是将有缺陷的药片与名义药片分开。在表征的情况下，要从一部分测得的共振频率中提取片剂的涂层厚度和机械性能，就需要进行迭代计算。在压实监测实验中，采用仪器化的冲头和圆柱形模具提取压实过程中片剂的弹性。为了研究压实动力学对片剂性能和缺陷的影响，对单层和双层片剂进行了有限元分析。还证明了一种非接触式粘合功技术可确定药物粉末颗粒的粘合功。

著录项

  • 作者

    Akseli, Ilgaz.;

  • 作者单位

    Clarkson University.;

  • 授予单位 Clarkson University.;
  • 学科 Chemistry Pharmaceutical.;Physics Acoustics.;Engineering Mechanical.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 268 p.
  • 总页数 268
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药物化学;机械、仪表工业;声学;
  • 关键词

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