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首页> 外文学位 >Injectable, in situ polymerizable, biodegradable scaffolds based on poly(propylene fumarate) for guided bone regeneration.
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Injectable, in situ polymerizable, biodegradable scaffolds based on poly(propylene fumarate) for guided bone regeneration.

机译：基于聚富马酸丙二醇酯的可注射，就地可聚合，可生物降解的支架，用于引导骨再生。

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Poly(propylene fumarate) (PPF) was developed as a scaffold to guide bone regeneration. Synthesis of this material via refined reaction pathways led to increased purity and higher molecular weights of this unsaturated, linear polyester. Due to its unsaturated nature, PPF can be formulated as an injectable composite through the incorporation of a vinyl monomer (N-vinyl pyrrolidinone), a leachable porogen (sodium chloride), and a particulate phase ({dollar}beta{dollar}-tricalcium phosphate). Variations in this formulation led to the development of a material that can cure in situ at body temperature, resulting in a scaffold with mechanical properties equivalent to human trabecular bone. The composite formulation was altered to determine its effect on the time course of degradation under both in vitro and in vivo conditions. Inflammatory response upon subcutaneous implantation was monitored during in vivo degradation, with all composite formulations eliciting a mild initial inflammatory response followed by thin fibrous encapsulation.; Marrow stromal cells were used to develop a model for in vitro bone formation. Osteogenic supplements were added early in the culture time frame to optimize the proliferation of these cells, as well as their differentiation into osteoblasts. PPF/{dollar}beta{dollar}-tricalcium phosphate composites provided an osteoconductive surface for the proliferation and differentiation of marrow-derived cells. Additionally, delivery of growth factors to induce bone regeneration was investigated by incorporating transforming growth factor beta-1 into biodegradable microspheres. Increased proliferation and osteoblastic differentiation of marrow-derived cells was observed when they were maintained in the presence of the growth factor-loaded microparticles.
机译：聚富马酸丙二酯（PPF）被开发为一种支架，可以引导骨骼再生。通过精制的反应途径合成该材料导致该不饱和线性聚酯的纯度提高和分子量更高。由于其不饱和性质，PPF可以通过掺入乙烯基单体（N-乙烯基吡咯烷酮），可浸出的致孔剂（氯化钠）和颗粒相（{美元}β{美元}-三钙）制成可注射复合材料。磷酸盐）。这种配方的变化导致了可以在体温下原位固化的材料的开发，从而产生了具有与人的小梁骨同等机械性能的支架。改变复合制剂以确定其在体外和体内条件下对降解时间进程的影响。在体内降解期间监测皮下植入后的炎症反应，所有复合制剂引起轻度的初始炎症反应，然后进行纤细的纤维包封。骨髓基质细胞用于建立体外骨形成模型。在培养时间的早期添加成骨补品，以优化这些细胞的增殖以及分化为成骨细胞。 PPF / {dollar}β{dollar}-磷酸三钙复合物为骨髓衍生细胞的增殖和分化提供了骨传导性表面。此外，通过将转化生长因子β-1掺入可生物降解的微球中，研究了诱导骨骼再生的生长因子的递送。当它们在存在生长因子的微粒存在下维持时，观察到骨髓来源的细胞增殖和成骨细胞分化增加。

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