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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Injectable and biodegradable composite bone filler composed of poly(propylene fumarate) and calcium phosphate ceramic for vertebral augmentation procedure: An in vivo in vivo porcine study
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Injectable and biodegradable composite bone filler composed of poly(propylene fumarate) and calcium phosphate ceramic for vertebral augmentation procedure: An in vivo in vivo porcine study

机译：由聚（丙烯富马酸丁酸酯）和椎弓根磷酸钙陶瓷组成的可注射和可生物降解的复合骨填料：体内猪研究中的体内

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Abstract Despite its common usage in vertebral augmentation procedures (VAPs), shortcomings of commercial polymethylmethacrylate (PMMA) still remain. Accordingly, injectable and biodegradable composite cements, which are composed of poly(propylene fumarate)/α‐tricalcium/hydroxyapatite (PPF/α‐TCP/HAP) and PPF/tetracalcium phosphate/dicalcium phosphate (PPF/TtCP/DCP), were developed. A porcine model was used and cylindrical holes in critical size were created at the center of the lateral cortex of vertebral bodies of the lumbar spine. A fixed volume of testing materials and PMMA were randomly injected into the defects. Results showed that both composite groups had a comparable radiolucency as PMMA but a significantly lower setting temperature. Histological inspections revealed new bone formation and remodeling along the border of the two composite cements. New bone substitution and irregular sclerotic bone mantles were found along the composite cements but not in the PMMA group. Radiological and histological changes were observed in the two composite groups and these modifications were diminished along the block boundaries. These findings imply gradual substitution of decomposed composite by new bone formation, which could not be found around the PMMA block. Comparing PPF/α‐TCP/HAP with the PPF/TtCP/DCP cement block, smaller particles that were spreading out were observed in the TtCP/DCP group, which represents rapid degradability. In conclusion, the composite cements have advantages such as a low setting temperature, radio‐opacity, biodegradability, and osteoconductivity. The injectable PPF/calcium phosphate ceramic composite has the potential to be used in VAPs. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2232–2243, 2017.
机译：摘要尽管其常见的椎体增强程序（VAP），但仍然存在商业聚甲基丙烯酸甲酯（PMMA）的缺点。因此，开发了由聚（丙烯氟化物）/α-β-羟基磷灰石（PPF /α-TCP / HAP）和PPF /四钙/二磷酸钙（PPF / TTCP / DCP）构成的可注射和可生物降解的复合柱。 。使用猪模型，并在腰椎椎体的侧面皮质的中心产生临界大小的圆柱孔。将固定体积的测试材料和PMMA随机注入缺陷。结果表明，两组复合基团都具有与PMMA相当的省略性，但设定温度明显较低。组织学检查揭示了沿两种复合水泥边界的新骨形成和重塑。沿复合水泥发现新的骨替代和不规则的硬化骨罩，但不在PMMA组中发现。在两种复合基团中观察到放射和组织学变化，并且这些修饰沿嵌段边界减少。这些发现意味着通过新的骨形成逐渐取代分解的复合材料，这在PMMA块周围无法找到。将PPF /α-TCP / HAP与PPF / TTCP / DCP水泥嵌段进行比较，在TTCP / DCP组中观察到散布的较小颗粒，其表示快速降解性。总之，复合水泥具有低设定温度，无透射块，生物降解性和骨导电性等优点。可注射的PPF /磷酸钙陶瓷复合材料具有在VAP中使用的电量。还2016 Wiley期刊，Inc.J生物保解率A件B：苹果生物摩特，105B：2232-2243，2017。

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