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首页> 外文学位 >The modelling and analysis of the dynamic performance of perfusion chromatography in fixed-bed and periodic countercurrent column operations and parameter estimation and model discrimination using experimental data.
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The modelling and analysis of the dynamic performance of perfusion chromatography in fixed-bed and periodic countercurrent column operations and parameter estimation and model discrimination using experimental data.

机译：在固定床和周期性逆流色谱柱操作中对灌注色谱的动态性能进行建模和分析，并使用实验数据进行参数估计和模型判别。

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摘要

Comparisons of dynamic simulation results for single and multi-component adsorption in columns operated in fixed bed and periodic countercurrent mode show that the periodic countercurrent operating mode nearly always gives superior performance. Furthermore, the performance of columns operated in the periodic countercurrent mode can be independent of the values of parameters that determine the mass transfer resistances of the system.; Simulation results over a range of values of several adsorbent particle structural and adsorption mechanism parameters show that intraparticle fluid flow in perfusive particles can improve adsorption system performance if it is of sufficient magnitude. However, performance with purely diffusive particles can be better than with perfusive particles, if purely diffusive particles can be made with higher values of C{dollar}rmsb{lcub}T{rcub}{dollar}, the maximum equilibrium concentration of adsorbate in the adsorbed phase of the adsorbent particle, than otherwise comparable perfusive particles.; A proposed method for parameter estimation in the Laplace transform domain is able to estimate intraparticle mass transfer parameters in linear adsorption models from simulated experimental data. The dynamic nonlinear model for purely diffusive particles having a monodisperse porous structure describes most appropriately experimental breakthrough data for the adsorption of bovine serum albumin onto porous anion-exchange particles packed in a column.
机译：在固定床和周期性逆流模式下对塔中单组分和多组分吸附的动态模拟结果进行比较，结果表明，周期性逆流操作模式几乎始终具有出色的性能。此外，以周期性逆流模式操作的色谱柱的性能可以独立于确定系统传质阻力的参数值。在几个吸附剂颗粒结构和吸附机理参数的值范围内的仿真结果表明，如果灌流颗粒足够大，颗粒内的流体流可以改善吸附系统的性能。但是，如果可以用更高的C {dollar} rmsb {lcub} T {rcub} {dollar}值制造纯扩散性颗粒，则纯扩散性颗粒的性能可能会优于灌注颗粒。吸附剂颗粒的吸附相，比其他可比较的灌注颗粒。在拉普拉斯变换域中提出的参数估计方法能够从模拟实验数据估计线性吸附模型中的颗粒内传质参数。具有单分散多孔结构的纯扩散颗粒的动态非线性模型描述了最合适的实验突破性数据，用于将牛血清白蛋白吸附到填充在色谱柱中的多孔阴离子交换颗粒上。

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