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Calcium-sensitive acceleration of wound closure in mechanically wounded endothelial cells.

机译：钙敏感加速机械损伤的内皮细胞的伤口闭合。

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Endothelial motility is an important response of the vasculature to injury. In vivo models of vascular injury indicate that full reendothelialization occurs in only small mechanical wounds (Reidy and Schwartz, 1981). In this work we have shown that scrape-wounding cultured endothelial monolayers results in the development of new adhesive contacts positively correlated with accelerated wound closure. A majority of these new contacts display close contact morphology and colocalize near active lamellapodium with the GTP-binding protein Rac and ;We further show that (i) cells displaying new adhesion, Rac redistribution and injury-derived Ca

机译：内皮运动是脉管系统对损伤的重要反应。体内血管损伤模型表明，完全的内皮再内皮化仅在较小的机械伤口中发生（Reidy和Schwartz，1981）。在这项工作中，我们已经表明，刮擦培养的内皮细胞单层可导致与加速伤口闭合成正相关的新粘合剂接触的发展。这些新接触中的大多数显示出紧密的接触形态，并与GTP结合蛋白Rac共同定位在活性层状细菌附近；我们进一步显示（i）细胞显示出新的黏附，Rac重新分布和损伤来源的Ca

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作者
Unger, Gretchen Moeller.;
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作者单位

University of Minnesota.;

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授予单位 University of Minnesota.;
学科 Biology Cell.;Biology Animal Physiology.;Health Sciences Pharmacology.
学位 Ph.D.
年度 1997
页码 138 p.
总页数 138
原文格式 PDF
正文语种 eng
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1. Comparison of V-Loc? 180 wound closure device and Quill? PDO knotless tissue-closure device for intradermal closure in a porcine in vivo model: evaluation of biomechanical wound strength. [J] . Kristen Gingras, Jeffrey Zaruby, Don Maul Journal of biomedical materials research. Part B, Applied biomaterials. . 2012,第4期

机译：比较V-Loc？ 180伤口闭合装置和鹅毛笔？ PDO无结组织闭合装置用于猪体内模型的皮内闭合：生物力学伤口强度评估。
2. Growth factors are released by mechanically wounded endothelial cells. [J] . P L McNeil, L Muthukrishnan, E Warder, Journal of cell biology . 1989,第2期

机译：机械损伤的内皮细胞释放生长因子。
3. Effect of Atropa belladonna L. on skin wound healing: biomechanical and histological study in rats and in vitro study in keratinocytes, 3T3 fibroblasts, and human umbilical vein endothelial cells. [J] . Gal P, Toporcer T, Grendel T, Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society . 2009,第3期

机译：颠茄对皮肤伤口愈合的影响：大鼠的生物力学和组织学研究以及角质形成细胞，3T3成纤维细胞和人脐静脉内皮细胞的体外研究。
4. Barbed, Bi-directional Medical Sutures: Biomechanical Propertiesand Wound Closure Efficacy Study [C] . Jeffrey C. Leung, Gregory L. Ruff, Matthew A. Megaro Annual meeting of the Society For Biomaterials . 2002

机译：带刺的双向医用缝合线：生物力学特性和伤口闭合功效研究
5. Deactivation and localization of stress-activated protein kinases in subconfluent and wounded vascular endothelial cells. [D] . Hamel, Marianne. 2001

机译：失活和损伤的血管内皮细胞中应力激活蛋白激酶的失活和定位。
6. Induced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model [O] . Zoë E. Clayton, Richard P. Tan, Maria M. Miravet, 2018

机译：诱导的多能干细胞来源的内皮细胞在鼠切除性伤口愈合模型中促进血管生成并加速伤口闭合
7. Improved Wound Closure Rates and Mechanical Properties Resembling Native Skin in Murine Diabetic Wounds Treated with a Tropoelastin and Collagen Wound Healing Device [O] . 2020

机译：改善伤口闭合率和机械性能，类似于用Tropoelastin和胶原伤口愈合装置处理的鼠糖尿病伤口中的天然皮肤

Calcium-sensitive acceleration of wound closure in mechanically wounded endothelial cells.

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