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Three-dimensional reconstruction of cerebral vasculature from limited digital subtraction angiographic projections.

机译：从有限的数字减影血管造影投影三维重建脑血管。

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摘要

An integrated approach is developed for 3D cone beam reconstruction of cerebral vasculature (both morphology and gray scale) from a limited number (4-6) of digital subtraction angiographic (DSA) projections, obtained using a standard biplane C-arm x-ray system. This provides an visualization tool for evaluating vascular relationships by the surgeons and neuroradiologists, in addition to quantification of stenoses and aneurysm sizes.;Problems in using ART in this work are evaluated by comparing reconstructions from experimentally obtained and idealized projection data. Limited view reconstruction method is demonstrated to be unstable. In addition, errors arising from geometric uncertainty, noise, and partial voluming are assessed with simulations. Corrective measures in reconstruction are described and demonstrated with experimental data.;Reconstruction of a phantom containing fiducial markers at known locations demonstrated that the reconstructed geometry is accurate to less than a pixel width (0.23 mm). The reconstruction algorithm with corrective measures is tested using (i) a high contrast thin wire phantom, (ii) an anatomic skull phantom with an embedded cerebral vasculature reproduction that includes an aneurysm, (iii) a human carotid artery, and (iv) a human cerebral vasculature with an aneurysm. The use of weight norm cut off and averaging ART for different terminal conditions is found to be effective with clinical data reconstructions. The reconstruction results validated by comparing experimental projections with reprojections of the 3D reconstruction gives encouraging results.;The reconstruction is performed iteratively using Algebraic Reconstruction Technique (ART) with non-negativity constraint. Accuracy of voxel gray scale values estimated by ART is improved by determining weights based on the intersection volume between a pyramidal ray and cubic voxel. The input data to the reconstruction is segmented, and corrected for spatial image distortion. The source and detector positions are also assumed to be known. The size of the reconstruction volume (512
机译：通过使用标准的双平面C臂X射线系统获得的有限数量（4-6）的数字减影血管造影（DSA）投影，开发了一种用于3D锥形束重建脑血管（形态和灰度）的集成方法。 。除了对狭窄和动脉瘤大小进行量化外，这还提供了一种可视化工具，可用于评估外科医生和神经放射科医生的血管关系。通过比较从实验获得的和理想的投影数据得到的重建结果，评估了这项工作中使用ART的问题。有限视图重建方法被证明是不稳定的。此外，还可以通过仿真评估几何不确定性，噪声和部分体积引起的误差。描述了重建中的纠正措施并通过实验数据进行了演示。在已知位置重建包含基准标记的体模表明，重建的几何形状精确到小于像素宽度（0.23 mm）。使用（i）高对比度细丝幻影，（ii）具有包括动脉瘤的嵌入式脑脉管系统复制的解剖颅骨幻影，（iii）人颈动脉和（iv）人的脑血管有动脉瘤。发现在不同的最终条件下使用权重标准截止和平均ART可以有效地重建临床数据。通过将实验投影与3D重建的重投影进行比较而验证的重建结果给出了令人鼓舞的结果。;使用具有非负约束的代数重建技术（ART）迭代执行重建。通过基于金字塔射线和立方体素之间的交点体积确定权重，可以提高ART估算的体素灰度值的准确性。对重建的输入数据进行分段，并针对空间图像失真进行校正。源和检测器的位置也被认为是已知的。重建体积的大小（512

著录项

  • 作者

    Sen, Anindya.;

  • 作者单位

    University of Minnesota.;

  • 授予单位 University of Minnesota.;
  • 学科 Biomedical engineering.;Medical imaging.;Morphology.
  • 学位 Ph.D.
  • 年度 1996
  • 页码 155 p.
  • 总页数 155
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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