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Clinical investigation of the dopaminergic system with PET and fluorine-18-fluoro-L-DOPA.

机译:PET和氟18-氟-L-DOPA对多巴胺能系统的临床研究。

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摘要

ositron Emission Tomography (PET) is a tool that provides quantitative physiological information. It is valuable both in a clinical environment, where information is sought for an individual, and in a research environment, to answer more fundamental questions about physiology and disease states. PET is particularly attractive compared to other nuclear medicine imaging techniques in cases where the anatomical regions of interest are small or when true metabolic rate constants are required. One example with both of these requirements is the investigation of Parkinson's Disease, which is characterized as a presynaptic motor function deficit affecting the striatum. As dopaminergic neurons die, the ability of the striatum to affect motor function decreases. The extent of functional neuronal damage in the small sub-structures may be ascertained by measuring the ability of the caudate and putamen to trap and store dopamine, a neurotransmitter. PET is able to utilize a tracer of dopamine activity, ;This thesis work deals with implementing and optimizing the many different elements that compose a PET study of the dopaminergic system, including: radioisotope production; conversion of aqueous
机译:正电子发射断层扫描(PET)是一种提供定量生理信息的工具。在临床环境中(为个人寻求信息)和研究环境中,回答有关生理学和疾病状态的更基本问题,这都是有价值的。在感兴趣的解剖区域较小或需要真正的代谢速率常数的情况下,与其他核医学成像技术相比,PET特别具有吸引力。满足这两个要求的一个例子是对帕金森氏病的研究,该病的特征是影响纹状体的突触前运动功能障碍。随着多巴胺能神经元死亡,纹状体影响运动功能的能力降低。可通过测量尾状和壳状核捕获和储存神经递质多巴胺的能力来确定小亚结构中功能性神经元损伤的程度。 PET能够利用多巴胺活性的示踪剂。本论文的工作涉及实现和优化组成PET研究多巴胺能系统的许多不同元素,包括:放射性同位素的产生;水的转化

著录项

  • 作者

    Oakes, Terrence Rayford.;

  • 作者单位

    The University of Wisconsin - Madison.;

  • 授予单位 The University of Wisconsin - Madison.;
  • 学科 Health Sciences Radiology.;Biophysics Medical.;Physics Radiation.
  • 学位 Ph.D.
  • 年度 1995
  • 页码 249 p.
  • 总页数 249
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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