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Recurrent synaptic inhibition in an oscillatory neuronal network.

机译：振荡神经元网络中的反复突触抑制。

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摘要

The PD neurons of the lobster stomatogastric ganglion are bursters which receive synaptic input from only the inhibitory LP neuron. This inhibition is recurrent, in that it is triggered by, and follows at a fixed latency after, every PD burst. The timing, duration, and strength of this input was controlled by manipulating LP; the PDs were also perturbed by injecting pulses and pairs of pulses of current intracellularly after removing input from LP. The results were summarized in a simple, linear model of the information processing properties of the PDs: the PDs compute a weighted average from endogenously and synaptically-supplied temporal information. This computation determines the timing of bursting discharge, but does not affect the duration or intensity of discharge if the input occurs in the interburst interval.; The recurrent input from LP normally makes the burst rhythm produced by the PDs more robust, in that the rhythm is less sensitive to perturbing input and undergoes less spontaneous variation in burst period. This effect of synaptic inhibition is a consequence of hyperpolarization, in that one hyperpolarizing input makes the PDs less sensitive to another perturbing input. Normal synaptic input does not affect the period of the rhythm because of its timing.; A new technique is described which makes it possible to functionally potentiate LP's synapse onto the PDs. In this technique, action potentials produced by LP trigger pulses of hyperpolarizing current injected intracellularly into the PDs. Potentiating LP's recurrent synapse onto the PDs in this way induces a qualitative change in the burst pattern produced by the PDs and LP: instead of producing regular, alternating bursting discharge, they produce patterns which are either irregular or which show complex periodicities. This occurs because strong hyperpolarization of the PDs in any one cycle increases the PDs' release of inhibitory transmitter onto LP in the following cycle.; These results show that a rhythm can be made more robust by incorporating recurrent inhibition, but that that input must not be so strong that it alters the dynamics of the network.
机译：龙虾胃胃神经节的PD神经元是突触，仅从抑制性LP神经元接收突触输入。这种抑制是反复出现的，因为它是由每个PD突发触发并以固定的延迟时间跟随的。此输入的时间，持续时间和强度通过操纵LP来控制；通过从LP移除输入后，通过在细胞内注入脉冲和电流对脉冲来扰动PD。在PD的信息处理属性的简单线性模型中总结了这些结果：PD从内源和突触提供的时间信息计算加权平均值。该计算确定了突发放电的时间，但是如果输入发生在突发间隔中，则不会影响放电的持续时间或强度。 LP的循环输入通常会使PD产生的突发节奏更加稳健，因为节奏对干扰输入的敏感度较低，并且突发周期的自发变化较小。突触抑制的这种效果是超极化的结果，因为一个超极化输入会使PD对另一种干扰输入的灵敏度降低。正常的突触输入由于其时机而不会影响节奏的周期。描述了一种新技术，该技术可以在功能上将LP的突触增强到PD上。在该技术中，由LP产生的动作电位触发细胞内注入PD的超极化电流脉冲。以这种方式将LP的反复突触增强到PD上，会导致PD和LP产生的猝发模式发生质的变化：与其产生规则的，交替的猝发放电，它们产生的模式要么不规则，要么显示出复杂的周期性。发生这种情况是因为在任何一个周期中PD的强超极化都会增加PD在下一周期中将抑制性递质释放到LP上。这些结果表明，通过结合反复抑制，可以使节奏更稳健，但是输入一定不能太强以至于改变网络的动态。

著录项

  • 作者

    Herterich, Norman.;

  • 作者单位

    University of California, San Diego.;

  • 授予单位 University of California, San Diego.;
  • 学科 Biology Neuroscience.
  • 学位 Ph.D.
  • 年度 1992
  • 页码 253 p.
  • 总页数 253
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;
  • 关键词

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