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首页> 外文学位 >Functional and metabolic responses to ischemia/reperfusion in the isolated, working rat heart: Effect of exercise training.
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Functional and metabolic responses to ischemia/reperfusion in the isolated, working rat heart: Effect of exercise training.

机译：在离体的工作大鼠心脏中对缺血/再灌注的功能和代谢反应：运动训练的效果。

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摘要

The effect of prior exercise training on the ability of the heart to recover contractile and hemodynamic function following ischemia and subsequent reperfusion was determined in isolated, working rat hearts. Male F344 rats, 8-9 weeks of age, underwent 11-16 weeks of treadmill training at three intensities; low and moderate steady-state endurance as well as high-intensity interval training. Hearts from all trained groups, independent of training intensity, showed dramatically ({dollar}sim{dollar}2-fold) improved cardiac function upon reperfusion following 25 minutes of global, normothermic ischemia. Recovery of cardiac output relative to pre-ischemic values increased from 36 {dollar}pm{dollar} 7% in the sedentary group to 61 {dollar}pm{dollar} 7%, 68 {dollar}pm{dollar} 9% and 73 {dollar}pm{dollar} 5% in low, moderate and interval trained groups, respectively. Increased intensity of training was associated with an improved post-ischemic work production. However, the greatest benefit of training occurred in the transition from a sedentary state to the lowest intensity of physical activity. Several known pathologic mechanisms affecting post-ischemic contractile function were evaluated prior to ischemia, at the end of ischemia prior to reperfusion, and during reperfusion. Hearts from trained animals were characterized by improved reperfusion coronary flow and lower coronary resistance. Relative to pre-ischemia, both ATP (62% vs. 44%) and PCr (107% vs. 56%) were higher during reperfusion in trained vs. sedentary hearts, respectively. In addition, training reversed the 2-fold increase in reperfusion calcium uptake found in sedentary hearts while increasing efficiency of work and a lowering diastolic stiffness. No differences due to training were seen in the metabolic response to ischemia alone nor in the indices of free-radical generation at any time.; In conclusion, prior exercise training appears to attenuate or reverse the pathologic response to ischemia/reperfusion. These data support epidemiological evidence in humans of a greater survivability following heart attack in trained individuals.
机译：在孤立的工作大鼠心脏中，确定了先前的运动训练对缺血和随后再灌注后心脏恢复收缩和血液动力学功能的能力的影响。 8-9周大的雄性F344大鼠在三种强度下进行了11-16周的跑步机训练。中低稳态耐力以及高强度间歇训练。 25分钟的全身性常温缺血再灌注后，来自所有训练组的心脏，无论训练强度如何，均显示出明显的（{dollar} sim {dollar} 2倍）心脏功能改善。相对于缺血前值，心输出量的恢复从久坐组的36 {pm} pm {dollar} 7％增至61 {dollar} pm {dollar} 7％，68 {dollar} pm {dollar} 9％和73在低，中度和间歇训练的组中，分别{dollar} pm {dollar}为5％。训练强度的增加与缺血后工作产生的改善有关。但是，训练的最大好处发生在从久坐状态到最低强度的身体活动中。在缺血前，再灌注前缺血结束时和再灌注过程中，评估了几种影响缺血后收缩功能的已知病理学机制。来自受过训练的动物的心脏的特征在于改善的再灌注冠状动脉血流和更低的冠状动脉抵抗力。相对于缺血前，在经过训练的心脏和久坐的心脏中，再灌注期间的ATP（62％比44％）和PCr（107％比56％）都更高。此外，训练可以使久坐的心脏中的再灌注钙摄取增加2倍，同时增加工作效率并降低舒张压。在任何时候，单独训练对缺血的代谢反应和自由基产生的指标均未见因训练引起的差异。总之，先前的运动训练似乎减弱或逆转了对缺血/再灌注的病理反应。这些数据支持了人类的流行病学证据，即受过训练的个体心脏病发作后具有更大的生存能力。

著录项

  • 作者

    Bowles, Douglas Kent.;

  • 作者单位

    The University of Texas at Austin.;

  • 授予单位 The University of Texas at Austin.;
  • 学科 Biology Animal Physiology.; Health Sciences General.
  • 学位 Ph.D.
  • 年度 1992
  • 页码 181 p.
  • 总页数 181
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生理学;预防医学、卫生学;
  • 关键词

  • 入库时间 2022-08-17 11:50:15

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