• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >The development of a near infrared spectroscopy system and its application for non invasive monitoring of cerebral blood and tissue oxygenation in the newborn infants.
【24h】

The development of a near infrared spectroscopy system and its application for non invasive monitoring of cerebral blood and tissue oxygenation in the newborn infants.

机译：近红外光谱系统的开发及其在新生儿脑血和组织氧合的无创监测中的应用。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This project had two main objectives. The first of these was to design and construct a spectroscopic instrument to monitor small changes in optical transmission across an infant's head at several near infrared wavelengths resulting from changes in the cerebral oxygenation status. The overall attenuation of light by brain tissue is very high and is dominated by the scattering properties of the tissue. Hence a major requirement of the instrument was the ability to measure spectral changes at very low light levels. Once the instrument was available, the second objective was to convert the measured changes in optical transmission into changes in the concentration of the naturally occurring chromophores oxyhaemoglobin, deoxyhaemoglobin and oxidised and reduced cytochrome c oxidase. An important aspect of the work was that the chromophore concentration measurements should be quantified in non- arbitrary units. Medical Physics is, by its nature, highly interdisciplinary and this is reflected in the introductory chapter which briefly covers the clinical problems, the medical science background and the technical aspects of monitoring the cerebral oxygenation status of newborn infants. The second and third chapters examine those constituents of brain tissue which absorb and scatter light and how the complication of multiple scattering can be dealt with in performing quantitative spectroscopy. The fourth and fifth chapters describe the technical details of the instrument design and construction from the initial step of setting its design specifications to the final testing of its performance. The sixth chapter examines the absorption characteristics of the main chromophores of interest namely oxyhaemoglobin, deoxyhaemoglobin and the cytochrome enzymes of the respiratory chain within the brain cells. A discussion on the interpretation of the redox state of the respiratory enzymes in terms of the metabolic state of the brain is also included. The final chapter describes the data analysis methods, the measurement of optical pathlengths in scattering media and introduces a non-linear modification to the Beer-Lambert law which improves the accuracy of the spectroscopic measurements in highly scattering media.
机译：该项目有两个主要目标。首先是设计和制造一种光谱仪，以监测由于大脑氧合状态变化而导致的几个近红外波长处婴儿头部的光传输中的微小变化。脑组织对光的总体衰减非常高，并且受组织的散射特性支配。因此，该仪器的主要要求是能够在非常低的光照水平下测量光谱变化。一旦有了仪器，第二个目的就是将测得的光传输变化转换为天然存在的生色团氧合血红蛋白，脱氧血红蛋白以及氧化和还原的细胞色素C氧化酶的浓度变化。这项工作的一个重要方面是，生色团浓度的测量应以非任意单位进行量化。医学物理学从本质上说是高度跨学科的，这在介绍性章节中得到了反映，该章简要介绍了临床问题，医学背景以及监测新生儿脑氧合状况的技术方面。第二章和第三章研究了吸收和散射光的脑组织成分，以及在进行定量光谱分析时如何处理多重散射的并发症。第四章和第五章介绍了仪器设计和构造的技术细节，从设定设计规范的初始步骤到性能的最终测试。第六章研究了感兴趣的主要发色团的吸收特性，即氧合血红蛋白，脱氧血红蛋白和脑细胞内呼吸链的细胞色素酶。还包括根据大脑的代谢状态来解释呼吸酶的氧化还原状态的讨论。最后一章介绍了数据分析方法，散射介质中光程的测量，并对Beer-Lambert定律进行了非线性修改，从而提高了高散射介质中光谱测量的准确性。

著录项

  • 作者

    Cope, Mark.;

  • 作者单位

    University of London, University College London (United Kingdom).;

  • 授予单位 University of London, University College London (United Kingdom).;
  • 学科 Medical imaging.;Biophysics.;Physiology.
  • 学位 Ph.D.
  • 年度 1991
  • 页码 343 p.
  • 总页数 343
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号