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首页> 外文学位 >Inhibition of Cancer Growth by O, S and N- Containing Schiff Bases Derived from 2, 2'-Bipyrdine-5,5'- dicarboxaldehyde.
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Inhibition of Cancer Growth by O, S and N- Containing Schiff Bases Derived from 2, 2'-Bipyrdine-5,5'- dicarboxaldehyde.

机译：由2、2'-联吡啶-5,5'-二甲醛衍生的含O，S和N的席夫碱抑制癌症的生长。

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摘要

Cancer is an assembly of different diseases characterized by abnormal cell growth. The most common types of cancers in women include breast, cervical and ovarian. Hence, there is a need to develop or identify drugs that can effectively be used to treat cancer. In this study, we are investigating the anticancer effects of O, S and N- Containing Schiff Bases Derived from 2,2'-Bipyrdine-5,5'-dicarboxaldehyde. For simplicity, the compounds are called N1, N2 and N3. The growth analysis of the four different types of cancer cells (A549 lung cancer cells, BT549 breast cancer cells, MCF7 breast cancer cells, and PC3 prostate cancer cells) were examined using the concentrations for N1: 25, 12.5, 6.3, 3.13, 1.6, 0.78, and 0.39 mug/mul. N2: 12.5, 6.3, 3.13, 1.6, 0.78, 0.39 and 0.194 mug/mul. N3: 50, 25, 12.5, 6.3, 3.13, 1.6, and 0.78 mug/mul. Growth analysis were measured using the viability indicator Alamar Blue and fluorescent spectrophotometry. Measurements of the growth of A549 cancer cell line show a significant difference at exposures to compound N1 at 25 ug/ul and N3 at 50 ug/ul. N2 had no effect on the growth of A549. Measurements of the growth of BT549 cancer cell line show no significant difference at all concentration of N1. Measurements of the growth of MCF7 cancer cell line show a significant difference at exposures to compound N1 at 25 ug/ul and N2 at 25 ug/ul. N3 had no effect on the growth of MCF7. Measurements of the growth of PC3 cancer cell line show no significant difference at exposures to compound N1. N2 show a difference at 12.5 ug/ul and N3 at 50 and 25ug/ul. These results indicate N1, N2 and N3 may vary in the pathway that causes growth inhibition in the four cell lines. This is a positive indicator that future studies may prove to increase our understanding of growth inhibition of cancer cells.
机译：癌症是多种以细胞异常生长为特征的疾病的集合。女性最常见的癌症类型包括乳腺癌，宫颈癌和卵巢癌。因此，需要开发或鉴定可以有效地用于治疗癌症的药物。在这项研究中，我们正在研究衍生自2,2'-联吡啶-5,5'-二甲醛的O，S和N含席夫碱的抗癌作用。为简单起见，这些化合物称为N1，N2和N3。使用N1的浓度检查了四种不同类型的癌细胞（A549肺癌细胞，BT549乳腺癌细胞，MCF7乳腺癌细胞和PC3前列腺癌细胞）的生长分析：25、12.5、6.3、3.13、1.6 ，0.78和0.39杯/米。 N2：12.5、6.3、3.13、1.6、0.78、0.39和0.194杯/米。 N3：50、25、12.5、6.3、3.13、1.6和0.78杯/米。使用活力指示剂Alamar Blue和荧光分光光度法测量生长分析。 A549癌细胞系生长的测量结果显示，暴露于25 ug / ul的化合物N1和50 ug / ul的N3时存在显着差异。 N 2对A549的生长没有影响。 BT549癌细胞系生长的测量结果显示，在所有浓度的N1下均无显着差异。 MCF7癌细胞系生长的测量结果显示，暴露于25 ug / ul的化合物N1和25 ug / ul的N2时存在显着差异。 N3对MCF7的生长没有影响。 PC3癌细胞系生长的测量结果显示，在暴露于化合物N1时无显着差异。 N2在12.5 ug / ul处显示出差异，N3在50和25ug / ul处显示出差异。这些结果表明N1，N2和N3可能会在导致四种细胞系生长抑制的途径中发生变化。这是一个积极的指标，表明未来的研究可能会证明加深了我们对癌细胞生长抑制的了解。

著录项

  • 作者

    Alqahtani, Zaina.;

  • 作者单位

    Tennessee State University.;

  • 授予单位 Tennessee State University.;
  • 学科 Chemistry.;Biochemistry.
  • 学位 M.S.
  • 年度 2016
  • 页码 67 p.
  • 总页数 67
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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