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首页> 外文学位 >REGULATORY MECHANISMS AND SYNAPTIC PHARMACOLOGY OF SEROTONERGIC NEURONS IN THE DORSAL RAPHE NUCLEUS, MEDIAN RAPHE NUCLEUS AND RAPHE PALLIDUS NUCLEUS IN MOUSE BRAIN SLICES IN VITRO.
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REGULATORY MECHANISMS AND SYNAPTIC PHARMACOLOGY OF SEROTONERGIC NEURONS IN THE DORSAL RAPHE NUCLEUS, MEDIAN RAPHE NUCLEUS AND RAPHE PALLIDUS NUCLEUS IN MOUSE BRAIN SLICES IN VITRO.

机译：小鼠脑片背侧RAPHE核，中性RAPHE核和RAPHE PALLIDUS核中5-羟色胺神经元的调控机制和突触药理学。

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摘要

Studies were designed to investigate the regulatory mechanism involved in maintaining the spontaneous activity of serotonergic neurons in the DRN, MRN and RPN. In vitro recordings were made within these nuclei in order to determine the effects of several different compounds on firing rates and cell/track ratios.; Neurons within the DRN, MRN and RPN displayed rhythmic discharge rates. Pretreatment with PCPA or treatment with high magnesium, low calcium produced no significant change in the firing rates of these neurons. Apparently, stringent levels of intracellular serotonin are not necessary for maintaining the spontaneous activity of serotonergic neurons.; Phenylephrine administration produced no change in discharge rates of DRN neurons in slices obtained from unanesthetized mice. However, phenylephrine dramatically increased the discharge rates and cell/track ratios of neurons in slices obtained from mice which were first anesthetized with halothane. These findings suggest that the spontaneous activity of serotonergic neurons is not dependent upon an excitatory noradrenergic input, but noradrenergic inputs apparently modulate the activity of serotonergic neurons under abnormal conditions.; Elevations of calcium levels in the incubation medium decreased the discharge rates and cell/track ratio of DRN neurons. High intracellular calcium may decrease the discharge rates of serotonergic neurons by increasing the afterhyperpolarization which follows each action potential.; Neurochemical data suggest that serotonin is synthesized at higher rates in the high calcium condition. Most of the excess neurotransmitter seems to be stored intracellular, since no 5-HIAA was detectable in the high calcium medium. These results are discussed in terms of their involvement in affective disorders such as depression.; Another set of experiments was designed to investigate the role of autoreceptors in the regulation of serotonergic neuronal activity. Autoreceptors appear to function by inhibiting serotonergic neuronal activity in the presence of excess serotonin in the slice.
机译：设计研究以研究涉及维持DRN，MRN和RPN中血清素能神经元自发活动的调节机制。为了确定几种不同化合物对发射速率和细胞/径迹比的影响，在这些核内进行了体外记录。 DRN，MRN和RPN中的神经元显示节律性放电速率。用PCPA预处理或用高镁，低钙治疗不会使这些神经元的放电速率发生明显变化。显然，维持血清素能神经元的自发活性不需要严格的细胞内血清素水平。苯肾上腺素的给药在未麻醉小鼠的切片中DRN神经元的放电速率没有变化。然而，去氧肾上腺素极大地增加了从首先用氟烷麻醉的小鼠获得的切片中神经元的放电速率和细胞/径迹比。这些发现表明，血清素能神经元的自发活动不依赖于兴奋性去甲肾上腺素能输入，但是在异常情况下，去甲肾上腺素能输入显然调节了血清素能神经元的活性。孵育培养基中钙水平的升高降低了DRN神经元的放电速率和细胞/径迹比。较高的细胞内钙可能通过增加跟随每个动作电位的超极化后能力来降低血清素能神经元的放电速率。神经化学数据表明，在高钙条件下，5-羟色胺的合成速率更高。大多数过量的神经递质似乎都储存在细胞内，因为在高钙培养基中没有检测到5-HIAA。根据这些结果与诸如抑郁之类的情感疾病的参与来讨论。设计另一组实验以研究自身受体在血清素能神经元活性调节中的作用。在切片中存在过量5-羟色胺的情况下，自体受体似乎通过抑制血清素能神经元活性发挥功能。

著录项

  • 作者

    CRISP, TERRIANN.;

  • 作者单位

    West Virginia University.;

  • 授予单位 West Virginia University.;
  • 学科 Biology Neuroscience.; Psychology Psychobiology.; Health Sciences Pharmacology.
  • 学位 Ph.D.
  • 年度 1985
  • 页码 136 p.
  • 总页数 136
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;心理学;药理学;
  • 关键词

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