• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >RELATIONSHIPS OF ZINC, COPPER, CHOLESTEROL AND ERYTHROCYTE OXIDANT STRESS IN SICKLE CELL ANEMIA.
【24h】

RELATIONSHIPS OF ZINC, COPPER, CHOLESTEROL AND ERYTHROCYTE OXIDANT STRESS IN SICKLE CELL ANEMIA.

机译：锌与铜，铜，胆固醇和红细胞氧化应激在细胞贫血中的关系。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aims of the present studies were to define the nature and mechanism of interaction of erythrocyte oxidant stress, plasma cholesterol (P-C), erythrocyte membrane cholesterol (M-C), plasma zinc (Zn) and plasma copper (Cu) in sickle cell anemia (SCA) patients. In one study, cholesterol (C) uptake by sickle erythrocytes was determined and shown to be elevated relative to normal erythrocytes. This increased C uptake was probably not due to: (1) a cell age effect since G-6PD deficient erythrocytes enriched with young cells did not show an increased C uptake, or (2) a plasma effect since cross incubation of sickle erythrocytes in control plasma and control erythrocytes in sickle plasma produced no difference. Some defect of sickle erythrocytes must underlie the greater C uptake.;Five studies tested whether the mechanism of low P-C in SCA patients involves Cu-mediated oxidation of C to inhibitory oxysterols. The results showed that (1) in vivo oxidant stress in rats did not significantly lower P-C, (2) elevated dietary Cu in rats did not lower P-C of normal or hypercholesterolemic rats, (3) Zn supplementation in SCA patients led to a rise in P-C in only some patients, (4) in untreated SCA patients, there were no Cu- or erythrocyte oxidant stress-related C differences, and (5) oxysterols were not systematically elevated in SCA patients. The proposed mechanism of low P-C was unsupported.;Relationships between Zn, Cu, C and erythrocyte oxidant stress may, nevertheless, exist as suggested by (1) the protective effect of elevated P-C or M-C against erythrocyte oxidant stress, (2) the rise in P-C in response to therapeutic Zn in some patients, (3) the association of Cu, measured as ceruloplasmin, with increased erythrocyte oxidant stress in untreated SCA patients and controls, and (4) the elevated oxysterols in one patient. Variations in these parameters may explain some of the clinical variability of sickle cell disease expression.;Three studies tested the effect of variations in P-C and M-C on erythrocyte oxidant stress. The results showed that erythrocyte oxidant stress was decreased (1) in sickle and control erythrocytes with in vitro elevated M-C, (2) in erythrocytes from rats with higher endogenous P-C, and (3) in erythrocytes from rats with dietary-induced P-C.
机译：本研究的目的是确定镰状细胞性贫血（SCA）中红细胞氧化应激，血浆胆固醇（PC），红细胞膜胆固醇（MC），血浆锌（Zn）和血浆铜（Cu）相互作用的性质和机理。 ） 耐心。在一项研究中，确定了镰状红细胞摄取的胆固醇（C）并显示相对于正常红细胞升高。增加的C吸收可能不是由于：（1）细胞年龄效应，因为富含年轻细胞的G-6PD缺陷型红细胞未显示出C吸收增加，或者（2）由于镰刀状红细胞在对照中交叉孵育，血浆效应镰状血浆中血浆与对照红细胞产生无差异。镰状红细胞的某些缺陷必须是更大的C吸收的基础。；五项研究测试了SCA患者低P-C的机制是否涉及Cu介导的C氧化为抑制性甾醇。结果表明：（1）大鼠体内的氧化应激不会显着降低PC，（2）大鼠饮食中的Cu升高不会降低正常或高胆固醇血症大鼠的PC，（3）SCA患者中的Zn补充导致维生素C升高。 PC仅在部分患者中存在；（4）在未经治疗的SCA患者中，没有与铜或红细胞氧化应激相关的C差异；（5）SCA患者中的氧固醇没有系统性升高。所提出的低PC的机理不受支持;;锌，铜，碳与红细胞氧化应激之间的关系可能仍然存在，如（1）PC或MC升高对红细胞氧化应激的保护作用，（2）升高在某些患者中，PC对治疗性Zn的反应是（3）以铜蓝蛋白计量的Cu与未经治疗的SCA患者和对照组的红细胞氧化应激增加相关，以及（4）在一名患者中氧固醇水平升高。这些参数的变化可能解释了镰状细胞疾病表达的某些临床变异性。三项研究测试了P-C和M-C变异对红细胞氧化应激的影响。结果表明，镰状和对照红细胞的M-C体外升高，红细胞的氧化应激降低，（2）内源性P-C较高的大鼠的红细胞，以及（3）饮食诱导的P-C的大鼠的红细胞减少。

著录项

  • 作者

    BEREZA, ULANA LYDIA.;

  • 作者单位

    University of Michigan.;

  • 授予单位 University of Michigan.;
  • 学科 Anthropology Physical.;Black Studies.
  • 学位 Ph.D.
  • 年度 1985
  • 页码 207 p.
  • 总页数 207
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号