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Biofunctionalization of titanium surfaces for dental implants: Osteogenic, anti-microbial and tribocorrosion resistant surfaces

机译：牙科植入物钛表面的生物功能化：成骨，抗微生物和抗摩擦腐蚀表面

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摘要

The rise of the worldwide dental implant market constantly increases the concerns regarding the quality, efficiency and lifetime of dental implants. Titanium based materials have shown proven ability for application in this field, essentially due to their adequate mechanical properties, corrosion behavior and biocompatibility. However, and despite the high success rates associated with dental implants, failures still continue to occur. Among the problems affecting the performance of dental implants, one can find: lack of osteointegration, propensity for bacterial colonization and corrosion/tribocorrosion processes. All these aspects are highly dependent on the surface properties of the implant. Ideally, implant surfaces should simultaneously promote adhesion of osteoblasts and inhibit the colonization by unwanted microorganisms. Furthermore, it is also necessary to minimize combined actions between corrosion and wear (tribocorrosion) that can cause degradation of the implant surface and ultimately lead to its failure. This thesis presents an approach to develop multifunctional titanium oxide surfaces with excellent tribocorrosion performance, while promoting a bio-selective behavior between the adhesion of osteoblastic cells and the minimization of bacterial colonization. For that purpose, surface modification of titanium by Micro-Arc Oxidation was performed, allowing the formation of a thick, adherent and porous titanium oxide structure with incorporated bioactive elements such as calcium, phosphorous, magnesium and zinc. A detailed characterization of the surfaces provided important insights for the understanding of the mechanisms of film formation. Moreover, the results allowed the correlation between chemical/structural properties of the oxide, and their effect on biological and tribocorrosion mechanisms. The surfaces developed in this work presented excellent tribocorrosion resistance, good interactions with osteoblastic cells, and promising antimicrobial properties.
机译：全球牙科植入物市场的兴起不断增加对牙科植入物的质量，效率和寿命的关注。钛基材料已显示出在该领域的应用能力，这主要是由于其足够的机械性能，腐蚀行为和生物相容性。然而，尽管与牙科植入物相关的成功率很高，但失败仍然继续发生。在影响牙科植入物性能的问题中，可以发现：骨整合不足，细菌定植的倾向和腐蚀/摩擦腐蚀过程。所有这些方面都高度取决于植入物的表面特性。理想地，植入物表面应同时促进成骨细胞的粘附并抑制有害微生物的定殖。此外，还必须使腐蚀和磨损（摩擦腐蚀）之间的综合作用最小化，这可能导致植入物表面退化并最终导致其失效。本论文提出了一种开发具有优异的摩擦腐蚀性能的多功能氧化钛表面的方法，同时促进了成骨细胞粘附与细菌定殖最小化之间的生物选择性行为。为此，通过微弧氧化对钛进行了表面改性，从而形成了厚的，附着的和多孔的氧化钛结构，并掺入了生物活性元素，例如钙，磷，镁和锌。表面的详细表征为理解成膜机理提供了重要的见识。而且，结果允许氧化物的化学/结构性质与其对生物学和摩擦腐蚀机理的影响之间的相关性。在这项工作中开发的表面表现出优异的抗摩擦腐蚀性能，与成骨细胞的良好相互作用，并有望实现抗菌性能。

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  • 作者

    Oliveira, Fernando Gabriel Machado de.;

  • 作者单位

    Universidade do Minho (Portugal).;

  • 授予单位 Universidade do Minho (Portugal).;
  • 学科 Biomedical engineering.
  • 学位 Ph.D.
  • 年度 2015
  • 页码 199 p.
  • 总页数 199
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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